Evidence map›Paper›PMID 40181161›Full record

ReviewNPJ precision oncology2025

Spatially precise chemo-radio-immunotherapy by antibody drug conjugate directed tumor radiosensitization to potentiate immunotherapies.

Mahsa Mortaja, Stephen R Adams, Rana R McKay, J Silvio Gutkind, Sunil J Advani

Abstract readReview
In one paragraph

Review in NPJ precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mahsa MortajaDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, 92093, USA.
Stephen R AdamsDepartment of Pharmacology, University of California San Diego, La Jolla, CA, 92093, USA.
Rana R McKayDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
J Silvio GutkindDepartment of Pharmacology, University of California San Diego, La Jolla, CA, 92093, USA.
Sunil J AdvaniDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, 92093, USA. sjadvani@health.ucsd.edu.

Funding

Elucidation and therapeutic exploitation of PAK mediated radioresistanceR37CA215081 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ADVANI, SUNIL J · 2018 to 2024
$2.5M
Spatially precise radio-chemo-immunotherapy using antibody conjugatesR01CA268513 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sunil J Advani · 2023 to 2026
$2.1M
NCI NIH HHS R01 CA268513NCI NIH HHS R37 CA215081NIH HHS CA215081NIH HHS CA268513
6 · The paper itself

Abstract

Concurrent chemo-radiotherapy is standard of care for locally advanced cancer patients. While radiotherapy and immuno-oncology have advanced precision oncology, chemotherapies in the chemo-radiotherapy paradigm remain non-targeted cytotoxins. Antibody drug conjugates offer an opportunity for targeted radiosensitization that stimulates immune responses while protecting normal tissues. Here, we discuss the rationale for combining antibody drug conjugates, radiotherapy and immunotherapies and opportunities for clinical translation to advance towards targeted chemo-radio-immunotherapy precision cancer care.

Identifiers

PMID40181161
PMCPMC11968929

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.