Evidence map›Paper›PMID 40181140›Full record

ArticleScientific reports2025

Preoperative pan-immuno-inflammatory values and albumin-to-globulin ratio predict the prognosis of stage I-III colorectal cancer.

Kejin Li, Yi Chen, Ziyi Zhang, Kuan Wang, Subinur Sulayman, Xiangyue Zeng, Saibihutula Ababaike, Junmin Guan, Zeliang Zhao

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Role of alternative splicing in cancer progression.Irish journal of medical science · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kejin LiDepartment of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical University, Ürümqi, 830011, China.
Yi ChenDepartment of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical University, Ürümqi, 830011, China.
Ziyi ZhangDepartment of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical University, Ürümqi, 830011, China.
Kuan WangDepartment of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical University, Ürümqi, 830011, China.
Subinur SulaymanDepartment of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical University, Ürümqi, 830011, China.
Xiangyue ZengDepartment of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical University, Ürümqi, 830011, China.
Saibihutula AbabaikeDepartment of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical University, Ürümqi, 830011, China.
Junmin GuanDepartment of Gastrointestinal Oncology Surgery, Gastroenterology Center, People's Hospital of Bortala Mongolian Autonomous Prefecture, Bole, 833499, China.
Zeliang ZhaoDepartment of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical University, Ürümqi, 830011, China. zlzhao71@163.com.

Funding

Natural Science Foundation of Xinjiang Uygur Autonomous Region 2022D01C297
6 · The paper itself

Abstract

This study evaluated the prognostic value of the pan-immune-inflammation value (PIV) combined with the albumin-to-globulin ratio (AGR) for postoperative survival in colorectal cancer (CRC) patients and developed a nomogram for survival prediction. A total of 650 CRC patients who underwent radical surgery were included, with data from one institution used as the training set. The optimal cut-off values for PIV (426.8) and AGR (1.4) were determined using maximally selected rank statistics. Kaplan-Meier analysis showed that patients in the low-PIV group had significantly better 5-year overall survival (OS) compared to the high-PIV group, while those in the high-AGR group had better 5-year OS than those in the low-AGR group. Multivariate analysis identified age, N stage, degree of differentiation, PIV, and AGR as independent prognostic factors for OS. A nomogram for OS was developed and validated, demonstrating robust predictive performance. This study highlights the value of PIV and AGR as reliable indicators for predicting OS in CRC patients, with high PIV and low AGR associated with worse prognosis. Timely interventions may improve patient outcomes.

Indexed as

Colorectal NeoplasmsGlobulinsSerum AlbuminSerum GlobulinsAdultAgedAged, 80 and overBiomarkers, TumorFemaleHumansInflammationKaplan-Meier EstimateMaleMiddle AgedNeoplasm StagingNomogramsBiomarkers, TumorGlobulinsSerum AlbuminSerum GlobulinsAlbumin-to‑globulin ratioColorectal cancerNomogramOverall survivalPreoperative immune-inflammatory valuesPrognosis

Identifiers

PMID40181140
PMCPMC11968868

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.