Evidence map›Paper›PMID 40181116›Full record

ArticleEye (London, England)2025

Dry eye disease treatment following refractive surgery among young patients: a population-based study.

Itay Nitzan, Dan Heller, Clara C Chan, Michael Mimouni, Margarita Safir

Abstract read
In one paragraph

Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Itay NitzanDepartment of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.ORCID http://orcid.org/0000-0001-6925-5157
Dan HellerDepartment of Military Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Clara C ChanDepartment of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-2886-2011
Michael MimouniDepartment of Ophthalmology, Rambam Health Care Campus, Haifa, Israel.ORCID http://orcid.org/0000-0002-4661-0993
Margarita SafirDepartment of Military Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. sapir.margarita@gmail.com.ORCID http://orcid.org/0000-0002-1814-8316

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the demand for dry eye disease (DED) lubricating eye drop treatment following refractive surgery among young patients.

methodsThis study involved Israeli adolescents and young adults aged 16-20 years who underwent systematic medical evaluations from 2011 to 2019. Refractive surgery status was determined based on medical records. Lubricating eye drop usage was monitored through computerized dispensation data over a three-year period. Regression models, stratified by sex and adjusted for sociodemographic variables, were used.

resultsAmong 591,919 individuals (57.4% male, mean age 17.2 years), 4571 (0.8%) underwent refractive surgery. Lubricating eye drop usage was observed in 1.4% of men and 2.3% of women, with higher proportions in the refractive surgery group (4.0% vs. 1.4% and 9.5% vs. 2.3% for men and women, respectively; p < 0.001). Adjusted odds ratios (aORs) for increased DED treatment durations in men were 2.34 (95% CI 1.94-2.83) for ≤3 months, 5.22 (95% CI 3.43-7.94) for 3 to 12 months, and 5.79 (95% CI 3.69-9.09) for over 12 months. For women, aORs were 3.68 (95% CI 2.50-5.41) for ≤3 months, 6.06 (95% CI 2.50-14.73) for 3-12 months, and 11.57 (95% CI 4.74-28.25) for over 12 months.

conclusionsYoung patients after refractive surgery are significantly more likely to require DED lubricating eye drops for over a year following the procedure.

Indexed as

Dry Eye SyndromesLubricant Eye DropsRefractive Surgical ProceduresAdolescentFemaleHumansIsraelMaleRetrospective StudiesYoung AdultLubricant Eye Drops

Identifiers

PMID40181116
PMCPMC12209430

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.