ArticleScientific reports2025
The interaction between ΔNp63α and TAp63α, mediated by miR-205-5p, inhibits the migration of lung adenocarcinoma cells.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Multimodal urinary biomarker panel achieves superior prostate cancer detection accuracy and reduces unnecessary biopsies.Translational oncology · 2026Article
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3 authors.
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Abstract
Lung cancer is a highly lethal disease worldwide, resulting from a combination of genetic, epigenetic, and environmental factors. The amplification of specific chromosomal regions is a hallmark of cancer progression; for instance, the 3q region of chromosome 3 is notably amplified in lung cancer, contributing to early tumor development. TP63, a member of the p53 family, is located in the 3q region. The presence of two distinct sets of TP63 isoforms (ΔNp63 and TAp63) complicates its functional role. Furthermore, miR-205-5p, a crucial player in cancer progression, has a predicted target site in the 5'-untranslated region (5'-UTR) of TAp63 transcripts. To investigate a potential correlation between miR-205-5p and the ΔNp63 and TAp63 isoforms, we conducted an in silico study followed by experimental validations on clinical tissue samples. We found a significant positive correlation between the expression of miR-205-5p and both isoforms of TP63 in lung adenocarcinoma (LUAD) datasets. The correlation between ΔNp63 and miR-205-5p was further confirmed in tissue samples from LUAD patients. Subsequently, we overexpressed ΔNp63α in lung adenocarcinoma cell lines and observed an upregulation of miR-205-5p, TAp63α, and DICER in the A549 cell line. Overexpression of ΔNp63α also inhibited the migration of A549 cells by reducing epithelial-mesenchymal transition (EMT) markers and increasing mesenchymal-epithelial transition (MET) markers. We conducted a luciferase assay to investigate the direct interaction between miR-205-5p and the 5'-UTR of TAp63 and observed a positive association. Overexpression of miR-205-5p in the A549 cell line led to the upregulation of TAp63α and DICER. Additionally, we found a reduction in migration following miR-205-5p transfection. Based on these results, it appears that there is a ΔNp63α/miR-205-5p/TAp63α/DICER axis involved in the regulation of migration in lung adenocarcinoma, which is cell-specific.
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