ArticleScientific reports2025
The role and function validation of P2RX4 as a novel cancer biomarker in pan-cancer analysis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Aberrant alternative splicing of purinergic receptor P2RX4 prevents sensitivity towards combinatorial treatment in colorectal and pancreatic cancer.The Journal of pathology · 2026Article
- High levels of P2RX5 expression predicts a poor prognosis and promotes tumor progression in endometrial cancer.International journal of clinical and experimental pathology · 2026Article
- Hotspots and frontiers of the relationship between hepatocellular carcinoma and cancer-associated fibroblasts: a bibliometric analysis and review.Discover oncology · 2025Article
- P2RX4 promotes hepatocellular carcinoma progression via calcium-mediated PI3K/AKT activation and immune remodeling.World journal of surgical oncology · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Purinergic Receptor P2X4 (P2RX4) is implicated in the carcinogenesis of several cancers, but no extensive study on its role in different forms of cancer. Expression level, gene mutation, immune infiltration, pathway enrichment, and prognostic value analysis of P2RX4 were performed based on multiple publicly available databases such as TCGA, GTEx, GEO, TIMER2, cBioportal, and Metascape databases. Western blot and RT-qPCR were used to identify P2RX4 expression in liver hepatocellular carcinoma (LIHC) and paracancer samples. P2RX4 was knocked in glioblastoma cell line (U251) and prostate cancer cell line (PC3), and its effects on cell viability, apoptosis, migration and invasion were investigated through cell counting kit-8 assay, flow cytometry, wound healing and trasnwell assays, respectively. P2RX4 expression was elevated in most cancers, which predicted poor overall survival and disease-free survival. Mutations in P2RX4 were predominantly found in Lymphoid Neoplasm Diffuse Large B-cell Lymphoma (> 4%). P2RX4 expression showed a positive correlation with the infiltration levels of cancer-associated fibroblasts and CD8 + cells in multiple tumor types. Functional enrichment analysis indicated that P2RX4 is closely related to autophagy, protein modification or intracellular trafficking. P2RX4 was highly expressed in LIHC compared to paracancerous tissues. Knockdown of P2RX4 suppressed cell viability, migration, invasion, and promoted cell apoptosis of U251 and PC3 cells. Overexpression of P2RX4 occurred in multi cancers, and was connected to an unfavorable prognosis. This pan-cancer analysis highlighted the predictive value and tumorigenic role of P2RX4.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.