ArticleScientific reports2025
Evaluation of the efficacy of P11-4 and CCP-ACPF in the prevention and treatment of white spot lesions: a multi-technique approach.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Effect of Various Types of Remineralizing Agents on the Remineralization of Mild and Moderate Defects Caused by Molar-Incisor Hypomineralization in Mexican Schoolchildren: A 12-month Follow-up Randomized Clinical Trial.Oral health & preventive dentistry · 2026Trial
- A prospective, triple-blind, randomized controlled clinical trial evaluating the protective effect of P11-4 peptide on enamel demineralization during multibracket orthodontic treatment.BMC oral health · 2026Trial
- Comparative evaluation of remineralization agents in severe enamel hypomineralization using a porcine enamel model.BMC oral health · 2026Article
- Evaluation of the early effects of peptide-containing agents in sensitivity treatment regarding their structural, morphological, and elemental changes in dentin tissue and their penetration efficacy.Journal of applied oral science : revista FOB · 2026Article
- Prevalence of white spot lesions in children and adolescents across Northern, Central and Southern Italy: a multicenter cross-sectional study.Frontiers in oral health · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The aim of this study was to assess the efficacy of the self-assembling peptide P11-4 [Curodont Repair Fluoride Plus-self-assembling peptide (Curodont FP)] and casein phosphopeptide-amorphous calcium phosphate fluoride (CCP-ACPF) (MI Varnish) in the management of white spot lesions (WSLs), during orthodontic treatment. Eighty specimens were prepared from the buccal surfaces of bovine teeth and divided into five groups that received different treatment protocols with Curodont FP and MI Varnish. (1) MI- Pre-Post: MI varnish applied before and after demineralization; (2) MI-Post: MI varnish applied after demineralization; (3) Curodont- Pre-Post: Curodont FP applied before and after demineralization; (4) Curodont-Post: Curodont FP applied after demineralization; (5) Control: No remineralization agent applied after demineralization. MI Varnish was applied in a thin and uniform layer using a single-use brush. Before application of Curodont FP, the enamel surface was conditioned with 35% phosphoric acid, rinsed and gently air-dried, then applied with an applicator sponge. Generalized linear models and one-way ANOVA tests were used to analyze the data. The significance level was set at p < 0.05. Specimens were analyzed using micro-computed tomography (micro-CT), field-emission scanning electron microscopy (FE-SEM), and energy-dispersive X-ray spectroscopy (EDX). The lowest lesion depths after the 28-day period (T2) were observed in the MI-Pre-Post (0.14 mm), MI-Post (0.15 mm), and Curodont-Pre-Post (0.15 mm) groups (p = 0.003). The control group showed the lowest mineral density (2.28 gHA/cm
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