Evidence map›Paper›PMID 40180994›Full record

Observational studyScientific reports2025

COVID-19 infection was associated with poor sperm quality: a cross-sectional and longitudinal clinical observation study.

Lulu Yuan, Wei Sun, Zihan Dong, Lu Lu, Xiaobin Wang, Qiang Du, Renhao Guo, Ping Li, Xu Leng, Haizhen Liang and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lulu YuanCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No.39, Huaxiang Road, Tiexi District, Shenyang, 110022, Liaoning Province, People's Republic of China.
Wei SunResearch Center for Universal Health, School of Public Health, China Medical University, Shenyang, People's Republic of China.
Zihan DongGeneScience Pharmaceutical, Shenyang, People's Republic of China.
Lu LuJoint College of China Medical University and Queen's University of Belfast, China Medical University, Shenyang, People's Republic of China.
Xiaobin WangCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No.39, Huaxiang Road, Tiexi District, Shenyang, 110022, Liaoning Province, People's Republic of China.
Qiang DuCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No.39, Huaxiang Road, Tiexi District, Shenyang, 110022, Liaoning Province, People's Republic of China.
Renhao GuoCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No.39, Huaxiang Road, Tiexi District, Shenyang, 110022, Liaoning Province, People's Republic of China.
Ping LiCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No.39, Huaxiang Road, Tiexi District, Shenyang, 110022, Liaoning Province, People's Republic of China.
Xu LengCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No.39, Huaxiang Road, Tiexi District, Shenyang, 110022, Liaoning Province, People's Republic of China.
Haizhen LiangCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No.39, Huaxiang Road, Tiexi District, Shenyang, 110022, Liaoning Province, People's Republic of China.
Bochen PanCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No.39, Huaxiang Road, Tiexi District, Shenyang, 110022, Liaoning Province, People's Republic of China. panbochen@cmu.edu.cn.ORCID http://orcid.org/0000-0002-1184-1003

Funding

345 Talent Project M1463Liaoning Provincial Government Education Department Project JYTMS20230102Shengjing Hospital Clinical Research Project M0071"Tree Planting" Project M1590
6 · The paper itself

Abstract

To ascertain whether COVID-19 infection affects sperm quality and measure the scale of the effects. A cross sectional study and a longitudinal study were conducted during the SARS-CoV-2 pandemic (from September 7th 2022 to late January 2023) in China. 604 patients participated in the cross sectional study; 140 in the longitudinal study with 149 unaffected natural controls. The cross sectional study included participants who produce semen sample after COVID-19. The longitudinal study included COVID-19 positive participants who could provide semen samples before and after the infection. In addition, patients unaffected by the infection who could provide two consecutive semen samples over the same period were included as controls for the longitudinal study. Conventional sperm quality parameters including sperm count, motility, morphology and more recent parameters such as sperm DNA fragmentation index (DFI) and sperm chromatin immaturity were observed. In the cross sectional study, the exposure group demonstrated significantly lower total sperm count (159.58 × 10

Indexed as

COVID-19SpermatozoaAdultChinaCross-Sectional StudiesDNA FragmentationHumansLongitudinal StudiesMaleMiddle AgedSARS-CoV-2Semen AnalysisSperm CountSperm MotilityCOVID-19 infectionSperm countSperm morphologySperm motilitySperm quality

Identifiers

PMID40180994
PMCPMC11968890

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.