Evidence map›Paper›PMID 40180956›Full record

ArticleNature communications2025

Robust super-structured porous hydrogel enables bioadaptive repair of dynamic soft tissue.

Siqi He, Weiwen Liang, Youchen Tang, Jinquan Zhang, Runxian Wang, Luna Quan, Yang Ouyang, Rongkang Huang, Ruoxu Dou, Dingcai Wu

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Immune-Responsive Bioinks Enable Vision-GuidedAdvanced functional materials · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
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  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Siqi He *Department of Gastrointestinal Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, P. R. China.ORCID http://orcid.org/0000-0002-8285-7715
Weiwen Liang *Department of General Surgery (Colorectal Surgery), Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, P. R. China.
Youchen Tang *The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, P. R. China.
Jinquan ZhangDepartment of Gastrointestinal Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, P. R. China.
Runxian WangDepartment of Gastrointestinal Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, P. R. China.
Luna QuanKey Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Yang OuyangDepartment of General Surgery (Colorectal Surgery), Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, P. R. China.
Rongkang HuangDepartment of General Surgery (Colorectal Surgery), Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, P. R. China. huangrk3@mail.sysu.edu.cn.
Ruoxu DouDepartment of Gastrointestinal Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, P. R. China. dourx@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-6572-1664
Dingcai WuKey Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, P. R. China. wudc@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0003-1396-0097

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Well-orchestrated integration of multiple contradictory properties into a single material is crucial for dynamic soft tissue defect repair but remains challenging. Bioinspired by diaphragm, we have successfully developed a robust super-structured porous hydrogel with anisotropic skeleton and asymmetric porous surfaces via integrated molding. Thanks to synergistic toughening of anisotropic structure and Hofmeister effect of amino acid, our hydrogel achieves high tensile strength (22.2 MPa) and elastic modulus (32.4 MPa) for strong mechanical support, while maintaining excellent toughness (61.9 MJ m

Indexed as

HydrogelsWound HealingAnimalsBiocompatible MaterialsBiomimetic MaterialsElastic ModulusFemalePorosityRabbitsTensile StrengthTissue ScaffoldsBiocompatible MaterialsHydrogels

Identifiers

PMID40180956
PMCPMC11968947

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.