ArticleNature communications2025
Separate brainstem circuits for fast steering and slow exploratory turns.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Redefining the central pattern generator for vertebrate locomotion.Nature reviews. Neuroscience · 2026Review
- Whole-body central processing of lateral line inputs encodes flow direction relative to the center-of-mass.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Supraspinal commands have a modular organization that is behavioral context specific.Current biology : CB · 2025Article
- Red Nucleus Excitatory Neurons Initiate Directional Motor Movement in Mice.Biomedicines · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Locomotion requires precise tuning of descending commands to scale turning movements, such as rapid steering during prey pursuit or shallow turns during exploration. We show that these two turn types are governed by distinct brainstem circuits. The rapid steering circuit involves excitatory V2a and inhibitory commissural V0d neurons, distributed across different brainstem nuclei. These neurons are coupled via gap junctions and activated simultaneously, ensuring rapid steering through asymmetrical activation of spinal motor neurons. The recruitment of this circuit correlates more with the degree of direction change than with locomotor frequency. Steering neurons are, in turn, controlled by a subset of V2a neurons in the pretectum, activated by salient visual input. In contrast, slow exploratory turns are governed by a separate set of V2a neurons confined to fewer brainstem nuclei. These findings reveal a modular organization of brainstem circuits that selectively control rapid steering and slow exploratory turning during locomotion.
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