ArticleNature communications2025
Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect.
Abstract read
In one paragraph
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nitrous oxide for the treatment of depression: a systematic review and meta-analysis.EBioMedicine · 2025Pooled it
- Diosgenin activates ERα-dependent PI3K/AKT/GSK3β signaling to enhance brain-derived serotonin and alleviate postmenopausal bone loss.Journal of advanced research · 2026Article
- Sex-specific electrophysiological and behavioral responses to nitrous oxide in a murine model of neuropathic pain.Biology of sex differences · 2026Article
- Rapid antidepressant potential of nitrous oxide: current state and major questions.Molecular psychiatry · 2026Review
- Nitrous oxide for late-life depression with inadequate antidepressant response: a randomised controlled trial.EClinicalMedicine · 2026Article
- Compensatory attenuation of cortical apoptosis by SK2 downregulation following ketamine anesthesia.Frontiers in pharmacology · 2026Article
- Rapid neonatal AAV delivery for adult cortical two-photon imaging of genetically encoded sensors.iScience · 2025Article
- Convergent Control of NREM Sleep and Anesthesia by Prefrontal Layer 5 Extratelencephalic Neurons.Research square · 2025Article
- Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain.Nature neuroscience · 2025Article
- Novel and emerging anesthetic drugs for the treatments of major depression: a comprehensive review of efficacy, mechanism, and outlook.Frontiers in psychiatry · 2025Review
- Nitrous Oxide Alters Functional Connectivity in Medial Limbic Structures in Treatment-Resistant Major Depression.medRxiv : the preprint server for health sciences · 2024Article
Corrections and comments
- Update of
Authors and funding
8 authors.
Joseph CichonDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. joseph.cichon@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0003-4318-9707
Thomas T JosephDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1323-3244
Xinguo LuDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Andrzej Z WasilczukDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1492-2319
Max B KelzDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-2803-6078
Steven J MennerickDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Charles F ZorumskiDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Peter NageleDepartment of Anesthesia and Critical Care, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-8369-3858
Funding
Neuroactive steroids as novel psychiatric treatments: mechanistic studiesP50MH122379 · NIMH · WASHINGTON UNIVERSITY · PI MAGUIRE, JAMIE LYNN · 2021 to 2025
$12.2MNEURONAL BASIS UNDERLYING VOLATILE ANESTHETIC INDUCED HYPNOSISR01GM088156 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KELZ, MAX · 2010 to 2021
$3.8MPhysician Postdoctoral Research Training in Perioperative Medicine (PPRTPM)T32GM112596 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Roderic G Eckenhoff, Max Kelz · 2015 to 2026
$3.4MGABAA RECEPTOR POPULATIONS IN HIPPOCAMPUS AND THALAMUSR01MH123748 · NIMH · WASHINGTON UNIVERSITY · PI MENNERICK, STEVEN J · 2021 to 2025
$2.4MBrain Wide Anesthetic-Active Neuronal NetworkR01GM151556 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Alexander Proekt · 2023 to 2026
$2.2MCellular and circuit mechanisms of the therapeutic action of inhaled nitrous oxide in rodent models of chronic stressR35GM151160 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI JOSEPH CICHON · 2023 to 2026
$1.7MEfficient prediction of transmembrane binding sites for anesthetic ligandsK08GM139031 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI JOSEPH, THOMAS THENGANPALLIL · 2020 to 2024
$984kNIGMS NIH HHS K08 GM139031NIGMS NIH HHS R01 GM088156NIGMS NIH HHS R01 GM151556NIGMS NIH HHS R35 GM151160NIGMS NIH HHS T32 GM112596NIMH NIH HHS P50 MH122379NIMH NIH HHS R01 MH123748U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM112596U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) K08GM139031U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM151160-01U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH122379
Abstract
Nitrous oxide (N
Indexed as
Antidepressive AgentsNitrous OxidePrefrontal CortexPyramidal CellsSmall-Conductance Calcium-Activated Potassium ChannelsAnimalsGyrus CinguliMaleMiceMice, Inbred C57BLNeuronsRatsReceptors, N-Methyl-D-AspartateAntidepressive AgentsKcnn2 protein, mouseNitrous OxideReceptors, N-Methyl-D-AspartateSmall-Conductance Calcium-Activated Potassium Channels
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.