ArticleProtoplasma2025
Acute and chronic toxicity study for Madhumukthi Kudineer Chooranum.
Article in Protoplasma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Madhumukthi Kudineer Chooranum (MKC) is a decoction from polyherbal Siddha formulation for managing diabetes. The safety of this formulation has not been reported earlier. This study evaluates the chronic toxicity of the Siddha herbal formulation MKC in experimental Sprague-Dawley (SD) rats. In an acute oral toxicity study, male and female SD rats were orally administered a single dose of MKC (2000 mg/kg), and clinical signs and mortality stages were observed for 14 days along with weekly body weight. On day 15, the rats were euthanized and the gross morphology was carried out during necropsy. In a chronic (repeated dose) oral toxicity study, the male and female rats were orally administered MKC (200, 400, and 800 mg/kg) once daily for up to 180 days. MKC showed outstanding tolerance in SD rats with a NOAEL of 2000 mg/kg, with no adverse effects or death during the study. In acute and chronic toxicity trials, MKC did not alter parameters or cause harmful effects. No group died or became moribund in either study.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.