Evidence map›Paper›PMID 40180626›Full record

ReviewMolecular biology reports2025

The role of plant-derived extracellular vesicles in ameliorating chronic diseases.

Ashwani Tiwari, Naveen Soni, Shweta Dongre, Megha Chaudhary, Bhawana Bissa

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Terpenoid-enrichedExtracellular vesicles and circulating nucleic acids · 2026
    Article
  9. Review
  10. Nanovesicles fromPharmaceuticals (Basel, Switzerland) · 2025
    Article
  11. Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ashwani TiwariDepartment of Biochemistry, Central University of Rajasthan, Ajmer, India.
Naveen SoniDepartment of Biochemistry, Central University of Rajasthan, Ajmer, India.
Shweta DongreDepartment of Biochemistry, Central University of Rajasthan, Ajmer, India.
Megha ChaudharyDepartment of Biochemistry, Central University of Rajasthan, Ajmer, India.
Bhawana BissaDepartment of Biochemistry, Central University of Rajasthan, Ajmer, India. Bhawana.bissa@curaj.ac.in.

Funding

Indian Council of Medical Research 52/27/2020-BIO/BMSScience and Engineering Research Board SRG/2020/000392
6 · The paper itself

Abstract

Plant-derived extracellular vesicles (PDEVs) have been shown to have a promising role in treating chronic illnesses. Plants secrete these vesicles containing bioactive chemicals such as proteins, lipids, nucleic acids, and small metabolites. Because of their unique structure, PDEVs affect many biological processes, which makes them an ideal candidate for treating the complex pathophysiology of chronic diseases. Recent studies have shown that PDEVs have anti-inflammatory and antioxidant properties. Extracellular vesicles (EVs) possess diverse therapeutic potential, including anti-inflammatory, antioxidant, and regenerative properties. By regulating immune responses, scavenging free radicals, and promoting tissue repair, EVs can address various chronic diseases such as cardiovascular disorders, neurological conditions, skin diseases, and inflammatory ailments. In preclinical models, PDEVs have been demonstrated to improve heart function and minimize the size of myocardial infarctions. In neurodegenerative illnesses, they can pass through the blood-brain barrier and deliver neuroprotective medicines to the brain. Furthermore, PDEVs have shown promise in enhancing insulin sensitivity and lowering hyperglycemia in diabetic animals. In this review article, we attempt to explain the diverse therapeutic potential of PDEVs in ameliorating chronic diseases.

Indexed as

Extracellular VesiclesPlantsAnimalsAnti-Inflammatory AgentsAntioxidantsCardiovascular DiseasesChronic DiseaseHumansNeurodegenerative DiseasesAnti-Inflammatory AgentsAntioxidantsCancerCardiovascular diseaseESCRTExosomesExtracellular vesiclesHuman diseasesNanovesiclesPDEVsPDNVs

Identifiers

PMID40180626

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.