Evidence map›Paper›PMID 40180601›Full record

ArticleLupus2025

Thrombocytopenia and autoimmune hemolytic anemia in antiphospholipid antibody-positive patients: Descriptive analysis of the AntiPhospholipid syndrome alliance for clinical trials and InternatiOnal networking (APS ACTION) clinical database and repository ("Registry").

Zeynep Belce Erton, Rebecca K Leaf, Danieli de Andrade, Ann Clarke, Maria G Tektonidou, Vittorio Pengo, Savino Sciascia, Jose Pardos-Gea, Nina Kello, Diana Paredes-Ruiz and 27 more

Registry-linked trialAbstract read
In one paragraph

Article in Lupus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07743242 (Autoimmune Hemolytic Anemia and Its Clinical Implication on Antiphospholipid Syndrome), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07743242 narecruitingnot on this mapstarted 2026, after this paper: background citation

Autoimmune Hemolytic Anemia and Its Clinical Implication on Antiphospholipid Syndrome

TypeinterventionalSponsorNew Valley UniversityRan2026 to 2028Enrolled230ConditionsAnti Phospholipid SyndromeArmsHemoglobin, Coombs test
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Zeynep Belce ErtonSUNY Downstate Medical Center, Brooklyn, NY, USA.ORCID 0000-0002-9099-8649
Rebecca K LeafMassachusetts General Hospital, Boston, MA, USA.
Danieli de AndradeUniversity of São Paulo, São Paulo, Brazil.ORCID 0000-0002-0381-1808
Ann ClarkeUniversity of Calgary, Calgary, AB, Canada.
Maria G TektonidouNational and Kapodistrian University of Athens, Athens, Greece.ORCID 0000-0003-2238-0975
Vittorio PengoPadova University Hospital, Padova, Italy.ORCID 0000-0003-2064-6071
Savino SciasciaDepartment of Clinical and Biological Sciences, University Center of Excellence on Nephrologic, Rheumatologic and Rare Diseases (ERK-Net, ERN-ReConnect and RITA-ERN Member) with Nephrology and Dialysis Unit and Center of Immuno-Rheumatology and Rare Diseases (CMID), ASL Città Di Torino and University of Turin, Turin, Italy.ORCID 0000-0003-1266-9441
Jose Pardos-GeaBioCruces Bizkaia Health Research Institute, Barakaldo, Spain.
Nina KelloNorthwell Health, Great Neck, NY, USA.
Diana Paredes-RuizBiobizkaia Health Research Institute, Barakaldo, Spain.
Chary Lopez-PedreraRheumatology Service, IMIBIC/Reina Sofia Hospital, University of Cordoba, Cordoba, Spain.
H Michael BelmontNew York University Langone Medical Center, New York, NY, USA.
Paul R FortinCentre ARThrite, CHU de Québec, Université Laval, Quebec, QC, Canada.
Guilherme Ramires de JesúsUniversidade Do Estado Do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID 0000-0002-6715-0180
Tatsuya AtsumiHokkaido University Hospital, Sapporo, Japan.
Zhouli ZhangPeking University First Hospital, Beijing, China.
Maria EfthymiouUniversity College London, London, UK.
D Ware BranchUniversity of Utah and Intermountain Healthcare, Salt Lake City, UT, USA.ORCID 0000-0002-1718-5094
Giulia PazzolaRheumatology Unit, Azienda USL IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Laura AndreoliUniversity of Brescia, Brescia, Italy.
Alí Duarte-GarcíaDivision of Rheumatology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-1749-5719
Esther Rodriguez-AlmarazHospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0003-0839-5644
Michelle PetriJohns Hopkins University, School of Medicin, Baltimore, MD, USA.ORCID 0000-0003-1441-5373
Ricard CerveraHospital Clinic Barcelona, Barcelona, Spain.ORCID 0000-0001-6085-492X
Bahar Artim-EsenIstanbul University School of Medicine, Istanbul, Turkey.ORCID 0000-0002-5659-3955
Rosana QuintanaCentro Regional de Enfermedades Autoinmunes y Reum´aticas Del Grupo Orono (GO-CREAR), Rosario, Argentina.ORCID 0000-0003-0643-2755
Hui ShiDepartment of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yu ZuoUniversity of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-6721-7755
Rohan WillisUniversity of Texas Medical Branch, TX, USA.ORCID 0000-0002-1374-7678
Megan R W BarberUniversity of Calgary, Calgary, AB, Canada.
Leslie SkeithUniversity of Calgary, Calgary, AB, Canada.
Massimo RadinDepartment of Clinical and Biological Sciences, University Center of Excellence on Nephrologic, Rheumatologic and Rare Diseases (ERK-Net, ERN-ReConnect and RITA-ERN Member) with Nephrology and Dialysis Unit and Center of Immuno-Rheumatology and Rare Diseases (CMID), ASL Città Di Torino and University of Turin, Turin, Italy.ORCID 0000-0003-1941-2606
PierLuigi MeroniUniversity of Milan, Milan, Italy.ORCID 0000-0002-3394-1451
Maria Laura BertolacciniSchool of Cardiovascular & Metabolic Medicine & Sciences, King's College London, UK.ORCID 0000-0002-8623-139X
Hannah CohenUniversity College London, London, UK.ORCID 0000-0003-2032-390X
Robert RoubeyUniversity of North Carolina, Chapel Hill, NC, USA.
Doruk ErkanBarbara Volcker Center for Women and Rheumatic Disease, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, USA.

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Clinical and Translational Science CenterUL1TR000457 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2012 to 2016
$46.0M
Thromboinflammatory consequences of infection-induced autoimmunityK08AR080205 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Yu Zuo · 2022 to 2026
$865k
NCATS NIH HHS UL1 TR000457NCATS NIH HHS UL1 TR001873NIAMS NIH HHS K08 AR080205
6 · The paper itself

Abstract

Background/PurposeAPS ACTION Registry was created to study the natural course of antiphospholipid syndrome (APS) over 10 years in persistently antiphospholipid antibody (aPL) positive patients with or without systemic autoimmune rheumatic diseases (SARDs). Our primary objective was to compare the characteristics of aPL-positive patients with or without thrombocytopenia (TP) and/or autoimmune hemolytic anemia (AIHA).MethodsThe registry inclusion criteria are positive aPL based on the Revised Sapporo APS Classification Criteria, tested at least twice within 1 year prior to enrollment. For the primary comparison of demographic, clinical, and serologic characteristics in this retrospective study, we divided patients into two groups: TP/AIHA ever and never. Thrombocytopenia was defined as a platelet count of <100,000 x 10

Indexed as

Anemia, Hemolytic, AutoimmuneAntibodies, AntiphospholipidAntiphospholipid SyndromeThrombocytopeniaAdultAgedDatabases, FactualFemaleHumansImmunosuppressive AgentsLupus Erythematosus, SystemicMaleMiddle AgedRegistriesRetrospective StudiesAntibodies, AntiphospholipidImmunosuppressive Agentsantiphospholipid antibodiesAntiphospholipid syndrome

Identifiers

PMID40180601
PMCPMC12177932

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.