Evidence map›Paper›PMID 40180587›Full record

ReviewGenetics2025

Origin and establishment of the germline in Drosophila melanogaster.

Ruoyu Chen, Sherilyn Grill, Benjamin Lin, Mariyah Saiduddin, Ruth Lehmann

Abstract readReview
In one paragraph

Review in Genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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  5. Article
  6. Article
  7. Current research in insect science · 2026
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruoyu ChenWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Sherilyn GrillWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Benjamin LinDepartment of Biochemistry & Cell Biology, Stony Brook University, Stony Brook, NY 11794, USA.
Mariyah SaiduddinWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Ruth LehmannWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.ORCID 0000-0002-8454-5651

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Cale Whitworth · 2014 to 2026
$13.5M
Germ Cell Migration in Drosophila.R01HD041900 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LEHMANN, RUTH · 2001 to 2012
$3.5M
Germ Cell Migration in Drosophila.R37HD041900 · NICHD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LEHMANN, RUTH · 2013 to 2021
$2.6M
Protecting and Sustaining Germ Cell IdentityR01HD110546 · NICHD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI RUTH LEHMANN · 2023 to 2026
$1.7M
Deconstructing fast amoeboid cell migrationR35GM157022 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Benjamin C Lin · 2024 to 2026
$1.2M
Uncovering the Mechanisms that Promote and Maintain Germ Cell IdentityK99HD113821 · NICHD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI GRILL, SHERILYN ANN · 2024 to 2025
$272k
American Cancer Society PF-21-116-01-RMCNational Institute of Child Health and Human Development R01/R37 HD41900NICHD NIH HHS K99 HD113821NICHD NIH HHS R01 HD041900NICHD NIH HHS R01 HD110546NICHD NIH HHS R37 HD041900NIGMS NIH HHS R35 GM157022NIH HHS 1R35GM157022NIH HHS P40 OD018537
6 · The paper itself

Abstract

The continuity of a species depends on germ cells. Germ cells are different from all the other cell types of the body (somatic cells) as they are solely destined to develop into gametes (sperm or egg) to create the next generation. In this review, we will touch on 4 areas of embryonic germ cell development in Drosophila melanogaster: the assembly and function of germplasm, which houses the determinants for germ cell specification and fate and the mitochondria of the next generation; the process of pole cell formation, which will give rise to primordial germ cells (PGCs); the specification of pole cells toward the PGC fate; and finally, the migration of PGCs to the somatic gonadal precursors, where they, together with somatic gonadal precursors, form the embryonic testis and ovary.

Indexed as

Drosophila melanogasterGerm CellsAnimalsCell DifferentiationFemaleMalebiomolecular condensatesgerm cellgerm granulesgermlinegermplasmgonadmitochondriaNanos, Tudor, Vasa, OskarPGC migrationpole cellsprimordial germ cellRNA localization

Identifiers

PMID40180587
PMCPMC12005264

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.