Evidence map›Paper›PMID 40180576›Full record

ArticleLife science alliance2025

Shared requirement for MYC upstream super-enhancer region in tissue regeneration and cancer.

Inderpreet Sur, Wenshuo Zhao, Jilin Zhang, Margareta Kling Pilström, Anna T Webb, Huaitao Cheng, Ari Ristimäki, Pekka Katajisto, Martin Enge, Helena Rannikmae and 2 more

Abstract read
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Inderpreet SurDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Wenshuo ZhaoDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Jilin ZhangDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-9976-1605
Margareta Kling PilströmDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Anna T WebbDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-6045-415X
Huaitao ChengDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Ari RistimäkiApplied Tumor Genomics Program, Biomedicum, University of Helsinki, Helsinki, Finland.
Pekka KatajistoDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-3033-4189
Martin EngeDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Helena RannikmaeDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
Marc de la RocheDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
Jussi TaipaleDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden jussi.taipale@ki.se.ORCID 0000-0003-4204-0951

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer has been characterized as a wound that does not heal. Malignant cells are morphologically distinct from normal proliferating cells but have extensive similarities to tissues undergoing wound healing and/or regeneration. The mechanistic basis of this similarity has, however, remained enigmatic. Here, we show that the genomic region upstream of

Indexed as

Enhancer Elements, GeneticNeoplasmsProto-Oncogene Proteins c-mycRegenerationAnimalsCarcinogenesisCell ProliferationHumansIntestinesMiceOrganoidsStem CellsMYC protein, humanProto-Oncogene Proteins c-myc

Identifiers

PMID40180576
PMCPMC11969384

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.