Evidence map›Paper›PMID 40180511›Full record

ReviewCurrent topics in developmental biology2025

Luteinizing hormone-induced changes in the structure of mammalian preovulatory follicles.

Corie M Owen, Laurinda A Jaffe

Abstract readReview
In one paragraph

Review in Current topics in developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Corie M OwenDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT, United States. Electronic address: coowen@uchc.edu.
Laurinda A JaffeDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT, United States. Electronic address: ljaffe@uchc.edu.

Funding

Signal Transduction at FertilizationR37HD014939 · NICHD · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI JAFFE, LAURINDA A. · 2014 to 2023
$4.8M
Role of LH-induced cell migration and cofilin dephosphorylation in ovulationF31HD107918 · NICHD · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI OWEN, CORIE MARIE · 2022 to 2023
$82k
NICHD NIH HHS F31 HD107918NICHD NIH HHS R37 HD014939
6 · The paper itself

Abstract

Ovulation of a mammalian oocyte from its follicle, which occurs in response to luteinizing hormone (LH), requires complex restructuring of the ∼20 layers of surrounding somatic cells. This chapter describes the cellular architecture of preovulatory follicles, the localization of the receptors for LH, and the LH-induced changes in follicular structure, focusing on mice and other small mammals. The multiple interrelated processes that result in ovulation include breakdown of existing extracellular matrix, generation of new extracellular matrix, thinning of the follicular apex where the oocyte will be released, invagination of the follicular surface, and responses of the vascular system to support these dynamic changes. However, much remains unknown about how these events function together to release a fertilizable egg.

Indexed as

Luteinizing HormoneOvarian FollicleOvulationAnimalsExtracellular MatrixFemaleMammalsMiceOocytesReceptors, LHLuteinizing HormoneReceptors, LHLuteinizing hormoneMammalOvaryOvulationPreovulatory follicle

Identifiers

PMID40180511
PMCPMC13249085

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.