Evidence map›Paper›PMID 40179959›Full record

ArticleNature2025

Strategic atom replacement enables regiocontrol in pyrazole alkylation.

Alexander Fanourakis, Yahia Ali, Liao Chen, Patrick Q Kelly, Abigail J Bracken, Christopher B Kelly, Mark D Levin

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Lactam Framework Editing via Formal Methylene Deletion.Journal of the American Chemical Society · 2026
    Article
  5. Article
  6. Shape-Conserving Atom Replacements.Chemical reviews · 2026
    Review
  7. Article
  8. Article
  9. SwitchingInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexander FanourakisDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Yahia AliDepartment of Chemistry, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0009-0000-4354-7338
Liao ChenDepartment of Chemistry, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0009-0001-3390-2698
Patrick Q KellyDepartment of Chemistry, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-0676-6317
Abigail J BrackenDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Christopher B KellyDiscovery Process Research, Johnson & Johnson Innovative Medicine, Spring House, PA, USA. ckelly5@its.jnj.com.ORCID http://orcid.org/0000-0002-5530-8606
Mark D LevinDepartment of Chemistry, University of Chicago, Chicago, IL, USA. marklevin@uchicago.edu.ORCID http://orcid.org/0000-0002-4461-363X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyrazoles are heterocycles commonly found as key substructures in agrochemicals and medicinally active compounds alike

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.