ArticleEnvironmental health perspectives2025
Prenatal and Childhood Phthalate Mixtures and Adolescent Sleep Health in the HOME Study.
Clara G Sears, Jessie P Buckley, Kim M Cecil, Heidi J Kalkwarf, Yingying Xu, Aimin Chen, Kimberly Yolton, Joseph M Braun
Abstract read
In one paragraphArticle in Environmental health perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Clara G SearsChristina Lee Brown Envirome Institute, Division of Environmental Medicine, Department of Medicine, University of Louisville, Louisville, Kentucky, USA.ORCID 0000-0002-5421-4077 Jessie P BuckleyDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Kim M CecilDepartment of Radiology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Heidi J KalkwarfDepartment of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Yingying XuDepartment of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Aimin ChenDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Kimberly YoltonDepartment of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Joseph M BraunDepartment of Epidemiology, Brown University, Providence, Rhode Island, USA.
Funding
Study of Prevalent Neurotoxicants in ChildrenP01ES011261 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI LANPHEAR, BRUCE P · 2001 to 2006
$6.4MLongitudinal Impact of Air Pollution on Mental Health and Neuroimaging Outcomes during Adolescence in the Cincinnati Combined Childhood Cohorts (C4)R01ES031621 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI CECIL, KIM M, RYAN, PATRICK H · 2021 to 2025
$5.3MEarly life perfluoroalkyl substance exposure & obesity: Mechanisms & phenotypingR01ES025214 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2016 to 2020
$3.1MInternalizing Behaviors and Neuroimaging Outcomes: Impact of PBDE and PFC ExposuresR01ES027224 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI CECIL, KIM M, YOLTON, KIMBERLY · 2016 to 2020
$3.0MLongitudinal study of exposure to PBDEs and PFCs and child neurobehaviorR01ES020349 · NIEHS · UNIVERSITY OF CINCINNATI · PI CHEN, AIMIN, LANPHEAR, BRUCE P · 2011 to 2015
$2.9MEndocrine Disrupting Chemicals, Thyroid Hormones, and Child NeurobehaviorR01ES024381 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2015 to 2018
$2.4MGestational PFAS Mixture Exposures, Longitudinal Metabolomic Profiles, and Adolescent Cardiometabolic HealthR01ES032836 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2021 to 2024
$2.4MEarly Life Phthalate and Perfluoroalkyl Substance Exposures and Childhood Bone HealthR01ES030078 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUCKLEY, JESSIE P · 2019 to 2023
$2.1MPre- and postnatal chemical mixture exposure, adolescent sleep health, and allostatic loadR01ES035133 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Clara G Sears · 2023 to 2026
$1.8MNIEHS NIH HHS P01 ES011261NIEHS NIH HHS R01 ES020349NIEHS NIH HHS R01 ES024381NIEHS NIH HHS R01 ES025214NIEHS NIH HHS R01 ES027224NIEHS NIH HHS R01 ES030078NIEHS NIH HHS R01 ES031621NIEHS NIH HHS R01 ES032836NIEHS NIH HHS R01 ES035133
6 · The paper itselfAbstract
backgroundThe biological mechanisms linking early life phthalate exposure with adverse behaviors and cardiometabolic conditions also impact sleep health, but whether early life exposure impacts adolescent sleep is unknown.
objectivesWe evaluated whether gestational and childhood urinary phthalate metabolite mixtures were associated with sleep characteristics during adolescence. We also examined periods of heightened susceptibility to individual phthalates.
methodsIn the Health Outcomes and Measures of the Environment (HOME) Study (Cincinnati, Ohio; 2003-2006;
resultsIncreasing all gestational phthalate metabolites by a quartile was associated with lower sleep efficiency [ DISCUSSION: Phthalate metabolite concentrations during pregnancy and childhood were associated with poorer adolescent sleep health. https://doi.org/10.1289/EHP15221.
Indexed as
Environmental ExposureEnvironmental PollutantsPhthalic AcidsPrenatal Exposure Delayed EffectsSleepAdolescentChildChild, PreschoolFemaleHumansInfantMaleOhioPregnancyEnvironmental Pollutantsphthalic acidPhthalic Acids
Identifiers
PMID40179323
PMCPMC12083775
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