Evidence map›Paper›PMID 40179319›Full record

ArticleAging2025

Decreased mitochondrial NAD+ in WRN deficient cells links to dysfunctional proliferation.

Sofie Lautrup, Shi-Qi Zhang, Shinichiro Funayama, Lisa Lirussi, Tina Visnovska, Hoi-Hung Cheung, Marc Niere, Yuyao Tian, Hilde Loge Nilsen, Geir Selbæk and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Sofie LautrupDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog 1478, Norway.
Shi-Qi ZhangDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog 1478, Norway.
Shinichiro FunayamaDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-0856, Japan.
Lisa LirussiDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog 1478, Norway.
Tina VisnovskaDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog 1478, Norway.
Hoi-Hung CheungSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
Marc NiereDepartment of Biomedicine, University of Bergen, Bergen 5009, Norway.
Yuyao TianSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
Hilde Loge NilsenDepartment of Microbiology, Oslo University Hospital, Oslo 0450, Norway.
Geir SelbækInstitute of Clinical Medicine, University of Oslo, Oslo 0372, Norway.
Janna SaarelaCentre for Molecular Medicine Norway (NCMM), University of Oslo, Oslo 0372, Norway.
Yoshiro MaezawaDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-0856, Japan.
Koutaro YokoteDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-0856, Japan.
Per NilssonDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Solna 17164, Sweden.
Wai-Yee ChanSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
Hisaya KatoDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-0856, Japan.
Mathias ZieglerDepartment of Biomedicine, University of Bergen, Bergen 5009, Norway.
Vilhelm A BohrDepartment of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen 1172, Denmark.
Evandro F FangDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog 1478, Norway.

Funding

EPIDEMIOLOGY OF FUNCTIONAL STATUS IN ELDERLY HISPANICSR01AG012975 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAAN, MARY N · 1997 to 2015
$13.8M
NIA NIH HHS R01 AG012975Wellcome Trust
6 · The paper itself

Abstract

Werner syndrome (WS), caused by mutations in the RecQ helicase WERNER (

Indexed as

Cell ProliferationMesenchymal Stem CellsMitochondriaNADWerner SyndromeWerner Syndrome HelicaseAnimalsCellular SenescenceFibroblastsHumansMiceNiacinamideNicotinamide PhosphoribosyltransferaseNADNiacinamideNicotinamide PhosphoribosyltransferaseWerner Syndrome HelicaseWRN protein, humanmitochondriaNAD+premature agingproliferationWerner syndrome

Identifiers

PMID40179319
PMCPMC12074813

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.