ArticleJournal of medicinal chemistry2025
Development of Next-Generation Antimalarial Acridones with Radical Cure Potential.
Abstract read
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Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Synthesis and antifungal and antitumor activities of acridine-containing tetrahydronaphthalene spiroisoxazoline derivatives.Molecular diversity · 2026Article
- An orally available PfPKG inhibitor blocks Plasmodium's infection of the liver.PLoS pathogens · 2026Article
- Revisiting 2-Substituted-4(1Journal of medicinal chemistry · 2026Article
- Evaluating acridones as novel therapeutics for human babesiosis.Antimicrobial agents and chemotherapy · 2026Article
- Ruthenium Complexes of Atovaquone Acting on Multiple Stages of theJournal of medicinal chemistry · 2026Article
- Identification of an Orally Efficacious Imidazo[4,5-Journal of medicinal chemistry · 2026Article
- Potent acridone antimalarial against all three life stages of Plasmodium.Nature communications · 2026Article
- Targeting Mitochondrial Function inInternational journal of molecular sciences · 2025Review
- Acridone Prodrugs with Enhanced Dual-Stage Antimalarial Efficacy.ACS medicinal chemistry letters · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
41 authors.
Rozalia A DodeanDepartment of Chemistry, Portland State University, Portland, Oregon 97201, United States.ORCID 0000-0001-5002-4607
Yuexin LiDepartment of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.
Xiaowei ZhangDepartment of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.
Diana CaridhaExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Michael S MadejczykExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Xiannu JinExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
William E DennisExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Ravi ChetreeExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Karl KudybaExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Sharon McEnearneyExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Patricia J LeeExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Cameron BlountExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Jesse DeLucaExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Chau VuongExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Kristina PannoneExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Hieu T DinhExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Kennedy MdakiExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Susan LeedExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Monica L MartinExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Brandon S PybusExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Sovitj PouDepartment of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.
Rolf W WinterDepartment of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.
Katherine M LiebmanDepartment of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.
Rachel WilliamsDepartment of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.
Amrendra KumarDepartment of Chemistry, Portland State University, Portland, Oregon 97201, United States.
Anongruk Chim-OngDepartment of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States.
Liwang CuiDepartment of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States.
Stephen OrenaInfectious Diseases Research Collaboration, Kampala, Uganda.
Jackson AssimweInfectious Diseases Research Collaboration, Kampala, Uganda.
Innocent TibagambirwaInfectious Diseases Research Collaboration, Kampala, Uganda.
Oswald ByaruhangaInfectious Diseases Research Collaboration, Kampala, Uganda.
Patrick AngutokoInfectious Diseases Research Collaboration, Kampala, Uganda.
Jennifer LegacDepartment of Medicine, University of California San Francisco, San Francisco, California 94143, United States.
Oriana KreutzfeldDepartment of Medicine, University of California San Francisco, San Francisco, California 94143, United States.
Philip J RosenthalDepartment of Medicine, University of California San Francisco, San Francisco, California 94143, United States.
Roland A CooperDepartment of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States.
Aaron NilsenDepartment of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.ORCID 0000-0002-3827-8222
Michael K RiscoeDepartment of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.ORCID 0000-0002-1343-5279
Alison RothExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Papireddy KancharlaDepartment of Chemistry, Portland State University, Portland, Oregon 97201, United States.ORCID 0000-0002-6381-1236
Jane X KellyDepartment of Chemistry, Portland State University, Portland, Oregon 97201, United States.ORCID 0000-0001-8871-0207
Funding
Resistance of Malaria Parasites to Artemisinin-Based TherapiesR01AI075045 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2009 to 2024
$8.4MMechanisms of varied sensitivity of P. falciparum field isolates to the antimalarial drug pipelineR01AI139179 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Philip Jon Rosenthal · 2018 to 2026
$6.3MSecond-Generation Novel Liver Stage Active AntimalarialsR01AI158533 · NIAID · PORTLAND STATE UNIVERSITY · PI KELLY, JANE X, ROTH, ALISON ELIZABETH · 2021 to 2025
$3.3MUnraveling the Drivers of Persistent Malaria Transmission in Cameroon: A Systems Approach (REDIAL)U19AI181593 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI LIWANG CUI · 2024 to 2026
$3.0MResistance of Malaria Parasites to Artemisinin-Based Combination TherapiesR56AI075045 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2008 to 2008
$618kBLRD VA I01 BX005674BLRD VA IK6 BX004857NIAID NIH HHS R01 AI075045NIAID NIH HHS R01 AI139179NIAID NIH HHS R01 AI158533NIAID NIH HHS R56 AI075045NIAID NIH HHS U19 AI181593
Abstract
Building from our previous lead compound T111 (
Indexed as
AcridonesAntimalarialsMalariaAnimalsDrug DevelopmentDrug ResistanceFemaleHumansMicePlasmodium bergheiPlasmodium cynomolgiPlasmodium falciparumStructure-Activity RelationshipAcridonesAntimalarials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.