Evidence map›Paper›PMID 40179233›Full record

ArticleThe Journal of clinical endocrinology and metabolism2025

Thyroid Hormone Sensitivity as a Possible Determinant of Metabolic Phenotypes in Young Adults, Not in Older Individuals.

Min-Hee Kim, Jeongmin Lee, Dong-Jun Lim, Kyle Masato Ishikawa, James Davis, Eunjung Lim, Hyeong Jun Ahn

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Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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0cells of the map it votes in
5citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Min-Hee KimDivision of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.ORCID 0000-0002-7506-5912
Jeongmin LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.ORCID 0000-0001-9074-8087
Dong-Jun LimDivision of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.
Kyle Masato IshikawaDepartment of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA.
James DavisDepartment of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA.
Eunjung LimDepartment of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA.
Hyeong Jun AhnDepartment of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA.ORCID 0000-0002-1510-1125

Funding

National Institute of Health 2U54MD007601-36National Institute of Health U54GM138062
6 · The paper itself

Abstract

contextAlthough thyroid hormones regulate metabolism, the relevance of thyroid hormone sensitivity indices in distinguishing metabolic phenotypes across age groups remains unclear.

objectiveWe evaluated the association between thyroid sensitivity indices and metabolic phenotypes, including metabolically healthy and unhealthy individuals with obesity (MHO, MUO) and normal weight (MHNW, MUNW), focusing on age-specific differences.

methodsData from participants aged 18 years and older in the National Health and Nutrition Examination Survey (NHANES) 2007 to 2012 were analyzed. Thyroid sensitivity indices, including the Thyroid Feedback Quantile-based Index (TFQI), Thyrotropin Index (TSHI), and Thyrotroph Thyroxine Resistance Index (TT4RI), were calculated. Multivariable regression and piecewise regression analyses were performed to examine associations between metabolic phenotypes and thyroid sensitivity indices, stratified by age groups (<65 and ≥65 years).

resultsIn the total population, the MUO group exhibited significantly higher values for TSHI (P = .035) compared to the MHNW group, while there were borderline and no significant differences for TT4RI (P = .093) and TFQI (P = .134), respectively. Among younger adults (<65 years), MUO showed the highest values for TSHI (β = 0.122; P = .006), TT4RI (β = 2.006; P = .010), and TFQI (β = 0.058; P = .018), with significant linear and quadratic trends (P < .05). No significant associations were observed in older adults (aged ≥65 years).

conclusionOur findings highlight the importance of thyroid sensitivity indices in understanding metabolic health, particularly among younger adults. Incorporating these indices into clinical assessments may enhance metabolic phenotype stratification and inform targeted management of obesity.

Indexed as

ObesityThyroid GlandThyroid Hormone Resistance SyndromeThyroid HormonesAdolescentAdultAgedAge FactorsCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition SurveysPhenotypeThyrotropinThyroid HormonesThyrotropinmetabolic phenotypesobesitythyroidthyroid sensitivity index

Identifiers

PMID40179233
PMCPMC12623034

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