ArticleScience (New York, N.Y.)2025
Meningeal regulatory T cells inhibit nociception in female mice.
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Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
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Who cites it
28 citing papers in PubMed.
- T cell-dependent modulation of pain behaviors in a rat model of recurring paclitaxel-induced peripheral neuropathy.Brain, behavior, & immunity - health · 2026Article
- Glial cells in neuropathic pain.Physiological reviews · 2026Review
- Neuroimmune interactions: from molecular mechanisms to therapeutic targets.Molecular biomedicine · 2026Review
- Review
- The basolateral amygdala decodes visceral pain and itch via distinct circuits and molecules.Nature communications · 2026Article
- Dorsal horn DCC amplification loop induced by endplate osteoclasts generates chronic nociplastic low back pain in male mice.Nature communications · 2026Article
- Effect of Preoperative Hormone Replacement Therapy on Postmenopausal Women Undergoing Rotator Cuff Repair.Cureus · 2026Article
- PRMT6 inhibition or deficiency attenuates diabetic neuropathic pain in male mice and is associated with reduced spinal neuroinflammation, microgliosis, and altered p53-p21 signaling.Journal of neuroinflammation · 2026Article
- T-cell distribution in the dorsal root ganglion across species, sex, and age.bioRxiv : the preprint server for biology · 2026Article
- Microbiome-derived metabolites alleviate chronic pain in a reserpine-induced model of fibromyalgia.iScience · 2026Article
- Targeting Pain and Depression in Alzheimer's Disease: Translational Insights and Emerging Treatments.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Human pain transcriptomics: lessons learned so far.Pain reports · 2026Review
- C/EBPβ Contributes to Cancer-Induced Bone Pain by Inhibiting CD200/CD200R1 in the Spinal Cord.CNS neuroscience & therapeutics · 2026Article
- CD38 endows local antigen-specific TNature immunology · 2026Article
- Regulatory T cells safeguard liver health during metabolic-associated steatohepatitis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The neuroimmune axis and chronic pain disorders.iScience · 2026Review
- Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception.Science immunology · 2025Article
- Immune system influence on physiology.Science (New York, N.Y.) · 2025Review
- Interleukin-4 induces CD11ceLife · 2025Article
- Delta opioid receptors: Overlooked outlier or the next big thing.Current opinion in pharmacology · 2025Review
Corrections and comments
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Authors and funding
12 authors.
Élora MidavaineDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-0364-8975
Beatriz C MoraesDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-5639-0050
Jorge BenitezDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.
Sian R RodriguezDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.ORCID 0009-0001-0440-1974
Joao M BrazDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8955-0735
Nathan P KochharDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.ORCID 0009-0005-3133-6484
Walter L EckalbarDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-2520-7852
Lin TianMax Planck Florida Institute for Neuroscience, Jupiter, FL, USA.ORCID 0000-0001-7012-6926
Ana I DomingosDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
John E PintarDepartment of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.ORCID 0000-0001-5945-569X
Allan I Basbaum *Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-1710-6333
Sakeen W Kashem *Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2594-2884
Funding
The next iteration of the AMP-T2D Knowledge PortalUM1DK105554 · NIDDK · BROAD INSTITUTE, INC. · PI BOEHNKE, MICHAEL L, BURTT, NOEL P · 2020 to 2025
$18.5MFrom the spinal cord to the brain: Neurology of the pain and itch neuronsR35NS097306 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BASBAUM, ALLAN I. · 2017 to 2024
$7.2MUCSF Dermatology Training GrantT32AR007175 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Wilson Liao, Michael David Rosenblum · 1986 to 2026
$6.1MNext generation all-optical toolkits for functional analysis of neuropeptide dynamics in neural circuitsU01NS113295 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BANGHART, MATTHEW R., SABATINI, BERNARDO L · 2019 to 2022
$3.7MMultiplex interrogation of neuromodulatory signaling in behaving animals with enhanced depth and resolutionU01NS120820 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TIAN, LIN, VONZASTROW, MARK E · 2021 to 2024
$3.5MGenetically encoded indicators for large-scale sensing of neuromodulatory signaling in behaving animalsU01NS103522 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NIMMERJAHN, AXEL, TIAN, LIN · 2017 to 2019
$2.9MCutaneous opioid circuitry in skin inflammation and sensationK08AR085766 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Sakeen W Kashem · 2025 to 2026
$372kSex-dependent control of nociception by meningeal regulatory T cellsK99NS142248 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Elora Midavaine · 2025 to 2026
$293kNIAMS NIH HHS K08 AR085766NIAMS NIH HHS T32 AR007175NIDDK NIH HHS UM1 DK105554NINDS NIH HHS K99 NS142248NINDS NIH HHS R35 NS097306NINDS NIH HHS U01 NS103522NINDS NIH HHS U01 NS113295NINDS NIH HHS U01 NS120820
Abstract
T cells have emerged as orchestrators of pain amplification, but the mechanism by which T cells control pain processing is unresolved. We found that regulatory T cells (T
Indexed as
MeningesNociceptionT-Lymphocytes, RegulatoryAnimalsEnkephalinsFemaleMaleMiceMice, Inbred C57BLReceptors, Opioid, deltaSensory Receptor CellsEnkephalinsReceptors, Opioid, delta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.