ArticleAnnals of clinical and translational neurology2025
Subthalamic Nucleus Oscillatory Characteristics in Meige, Cervical Dystonia and Generalized Dystonia.
Article in Annals of clinical and translational neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Acute and Chronic Local Field Potential Recordings in Dystonia-A Systematic Review.Movement disorders clinical practice · 2026Review
- Oscillatory dynamics in isolated dystonia: five hundred hours of chronic invasive multisite motor network recordings.Journal of neurophysiology · 2025Article
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Authors and funding
15 authors.
Funding
Abstract
objectiveDeep brain stimulation offers a unique opportunity to record neural activity of the basal ganglia. While much work in dystonia has focused on the globus pallidus internus, expanding research to investigate subthalamic nucleus (STN) activity in various dystonia types is critical to provide a comprehensive understanding of dystonia pathophysiology.
methodsSTN and cortex activity were recorded from 17 patients with cervical dystonia (CD), 19 with Meige syndrome, and 9 with generalized dystonia (GD) during the lead externalized period. We investigated local and network oscillatory characteristics, including power, bursts, and coherence. Additionally, we explored the relationship between these features and the severity of dystonic symptoms within each group and conducted a comparative analysis across the different dystonia types.
resultsPeaks of low-frequency (4-13 Hz) and beta (14-30 Hz) power were present in the STN of all patients; most of the beta peaks are distributed in the high beta range (20-30 Hz). The CD and GD groups showed longer low-frequency bursts and greater high beta power in STN than the Meige group. Interestingly, the CD group showed stronger STN-cortex low-frequency coherence, while the GD group had stronger STN-cortex high beta coherence. Combined, low-frequency and beta features could predict symptom severity with a performance of 73% in the CD group and 82% in the GD group.
interpretationLow-frequency and high-beta oscillations are present in the STN across all three types of dystonia. The distinct patterns may be associated with different underlying pathological mechanisms.
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