Evidence map›Paper›PMID 40179006›Full record

ArticlePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2025

Children Requiring 3 or More Days of Invasive Ventilation: Secondary Analysis of Post-Discharge Change in Caregiver Employment.

Kathryn E Kalata, Kristen R Miller, Yamila L Sierra, Tellen D Bennett, R Scott Watson, Peter M Mourani, Aline B Maddux

Abstract read
In one paragraph

Article in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Kathryn E KalataDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO.ORCID 0000-0001-5270-6521
Kristen R MillerDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO.
Yamila L SierraChild Health Research Enterprise, Pediatric Critical Care Medicine, Children's Hospital Colorado, Aurora, CO.
Tellen D BennettDepartment of Pediatrics, Section of Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO.
R Scott WatsonDepartment of Pediatrics, Division of Pediatric Critical Care Medicine, University of Washington School of Medicine and Center for Child Health, Behavior, and Development, Seattle Children's Research Institute, Seattle, WA.
Peter M MouraniDepartment of Pediatrics, Section of Critical Care, University of Arkansas for Medical Sciences and Arkansas Children's, Little Rock, AR.
Aline B MadduxDepartment of Pediatrics, Section of Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO.

Funding

Functional Outcomes after Prolonged Mechanical Ventilation in ChildrenK23HD096018 · NICHD · UNIVERSITY OF COLORADO DENVER · PI MADDUX, ALINE BERNARD · 2019 to 2023
$807k
NICHD NIH HHS K23 HD096018
6 · The paper itself

Abstract

objectivesTo describe frequency of, and risk factors, for change in caregiver employment among critically ill children with acute respiratory failure.

designPreplanned secondary analysis of prospective cohort dataset, 2018-2021.

settingQuaternary Children's Hospital PICU. PATIENTS: Children who required greater than or equal to 3 days of invasive ventilation, survived hospitalization, and completed greater than or equal to 1 post-discharge survey.

interventionsNone. MEASUREMENTS AND MAIN

resultsWe measured change in caregiver employment 1 and 12 months post-discharge relative to pre-admission and, when present, change in caregiver identity defined by relationship to the patient. Data were collected by survey. We used logistic regression to identify factors associated with these changes. We evaluated 130 children, median age 6.4 years (interquartile range, 1.10-13.3 yr), 40 (30.8%) with a complex chronic condition (CCC), and 99 (76.2%) with normal pre-illness Functional Status Scale scores. Of 123 with 1-month post-discharge data, 25 of 123 (20.3%) experienced a change in caregiver employment and an additional 14 of 123 (11.4%) had a change in caregiver(s). Of 115 with 12-month post-discharge data, 33 of 115 (28.7%) experienced a change in caregiver employment and an additional 16 of 115 (13.9%) had a change in caregiver(s). After controlling for age, CCC, baseline caregiver employment, new morbidity at discharge, and social and economic index; higher maximum Pediatric Logistic Organ Dysfunction-2 score (odds ratio [OR], 1.19 [95% CI, 1.01-1.41]) and government insurance (OR, 3.85 [95% CI, 1.33-11.11]) were associated with the composite outcome of change in caregiver employment or caregiver(s) at 1-month post-discharge.

conclusionsAt 1 and 12 months post-discharge, more than one-in-five children who survived greater than or equal to 3 days of invasive ventilation had a change in caregiver employment and one-in-ten had a change in caregiver(s). Identification of risk factors, such as illness severity and social determinants of health, associated with a significant family change may improve our support of these families.

Indexed as

CaregiversEmploymentRespiration, ArtificialRespiratory InsufficiencyAdolescentChildChild, PreschoolCritical IllnessFemaleHumansInfantIntensive Care Units, PediatricLogistic ModelsMalePatient DischargeProspective Studiescaregivercritical care outcomepediatric intensive care unitpediatric post-intensive care syndromesocial determinants of health

Identifiers

PMID40179006
PMCPMC11976063

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.