Evidence map›Paper›PMID 40178979›Full record

ArticleCell reports2025

A spatiotemporal cell atlas of cardiopulmonary progenitor cell allocation during development.

Hongbo Wen, Prashant Chandrasekaran, Annabelle Jin, Josh Pankin, MinQi Lu, Derek C Liberti, Jarod A Zepp, Rajan Jain, Edward E Morrisey, Sylvia N Michki and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hongbo WenDepartment of Pediatrics, Division of Cardiology, University of Pennsylvania, Children's Hospital of Philadelphia (CHOP), Penn-CHOP Lung Biology Institute, Penn Cardiovascular Institute, CHOP Cardiovascular Institute, Philadelphia, PA 19104, USA.
Prashant ChandrasekaranDepartment of Pediatrics, Division of Cardiology, University of Pennsylvania, Children's Hospital of Philadelphia (CHOP), Penn-CHOP Lung Biology Institute, Penn Cardiovascular Institute, CHOP Cardiovascular Institute, Philadelphia, PA 19104, USA.
Annabelle JinDepartment of Pediatrics, Division of Cardiology, University of Pennsylvania, Children's Hospital of Philadelphia (CHOP), Penn-CHOP Lung Biology Institute, Penn Cardiovascular Institute, CHOP Cardiovascular Institute, Philadelphia, PA 19104, USA.
Josh PankinDepartment of Pediatrics, Division of Cardiology, University of Pennsylvania, Children's Hospital of Philadelphia (CHOP), Penn-CHOP Lung Biology Institute, Penn Cardiovascular Institute, CHOP Cardiovascular Institute, Philadelphia, PA 19104, USA.
MinQi LuDepartment of Pediatrics, Division of Cardiology, University of Pennsylvania, Children's Hospital of Philadelphia (CHOP), Penn-CHOP Lung Biology Institute, Penn Cardiovascular Institute, CHOP Cardiovascular Institute, Philadelphia, PA 19104, USA.
Derek C LibertiDepartment of Pediatrics, Division of Cardiology, University of Pennsylvania, Children's Hospital of Philadelphia (CHOP), Penn-CHOP Lung Biology Institute, Penn Cardiovascular Institute, CHOP Cardiovascular Institute, Philadelphia, PA 19104, USA.
Jarod A ZeppDepartment of Pediatrics, Division of Pulmonary and Sleep Medicine, University of Pennsylvania, CHOP, Penn-CHOP Lung Biology Institute, Philadelphia, PA 19104, USA.
Rajan JainDepartment of Medicine, Department of Cell and Developmental Biology, Penn Cardiovascular Institute, Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Edward E MorriseyDepartment of Medicine, Department of Cell and Developmental Biology, Penn-CHOP Lung Biology Institute, Penn Cardiovascular Institute, Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Sylvia N MichkiDepartment of Pediatrics, Division of Cardiology, University of Pennsylvania, Children's Hospital of Philadelphia (CHOP), Penn-CHOP Lung Biology Institute, Penn Cardiovascular Institute, CHOP Cardiovascular Institute, Philadelphia, PA 19104, USA; Department of Pediatrics, Division of Pulmonary and Sleep Medicine, University of Pennsylvania, CHOP, Penn-CHOP Lung Biology Institute, Philadelphia, PA 19104, USA. Electronic address: michkin@chop.edu.
David B FrankDepartment of Pediatrics, Division of Cardiology, University of Pennsylvania, Children's Hospital of Philadelphia (CHOP), Penn-CHOP Lung Biology Institute, Penn Cardiovascular Institute, CHOP Cardiovascular Institute, Philadelphia, PA 19104, USA. Electronic address: frankd@chop.edu.

Funding

Molecular pathways controlling alveolar epithelial remodeling in development and regenerationR01HL132999 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MORRISEY, EDWARD E · 2016 to 2023
$4.6M
Multi-modal characterization of three human lung niches at the single cell levelU01HL148857 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MORRISEY, EDWARD E · 2019 to 2023
$4.4M
Deciphering how 3D genome organization orchestrates cardiac cellular identityR35HL166663 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Rajan Jain · 2023 to 2026
$3.5M
Manipulation of Host Tissue to Induce a Hierarchical MicrovasculatureR01HL167939 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI DINO J RAVNIC, Amir Sheikhi · 2023 to 2026
$3.2M
Mechanical signaling through the nuclear membrane in lung alveolar healthR01HL168803 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI EDWARD E MORRISEY · 2023 to 2026
$3.1M
Transcriptional Regulation of Lung Alveolar RegenerationR01HL152194 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MORRISEY, EDWARD E · 2021 to 2024
$2.3M
Wnt-mediated epithelial-endothelial crosstalk in the generation and regeneration of the lung alveolusK08HL140129 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI FRANK, DAVID BRIAN · 2018 to 2022
$797k
Defining the molecular determinants of mesenchymal lineage allocation in lung development and diseaseR00HL141684 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI ZEPP, JAROD · 2020 to 2022
$747k
CXCL12 signaling axis in pulmonary arterial heterogeneity, development, and diseaseR56HL167937 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI FRANK, DAVID BRIAN · 2023 to 2023
$657k
NHLBI NIH HHS K08 HL140129NHLBI NIH HHS R00 HL141684NHLBI NIH HHS R01 HL132999NHLBI NIH HHS R01 HL152194NHLBI NIH HHS R01 HL167939NHLBI NIH HHS R01 HL168803NHLBI NIH HHS R35 HL166663NHLBI NIH HHS R56 HL167937NHLBI NIH HHS U01 HL148857
6 · The paper itself

Abstract

The heart and lung co-orchestrate their development during organogenesis. The mesoderm surrounding both the developing heart and anterior foregut endoderm provides instructive cues guiding cardiopulmonary development. Additionally, it serves as a source of cardiopulmonary progenitor cells (CPPs) expressing Wnt2 that give rise to both cardiac and lung mesodermal cell lineages. Despite the mesoderm's critical importance to both heart and lung development, mechanisms guiding CPP specification are unclear. To address this, we lineage traced Wnt2

Indexed as

HeartLungStem CellsAnimalsCell LineageGene Expression Regulation, DevelopmentalMesodermMiceMyocytes, CardiacOrganogenesisSingle-Cell Analysiscell fateCP: Developmental biologydevelopmentheartlungprogenitor cellssingle-cell RNA sequencingWNT

Identifiers

PMID40178979
PMCPMC12103214

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.