Evidence map›Paper›PMID 40178924›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Ammoxidation of Unprotected Glycosides: A One-Pot Conversion of Alcohols to Nitriles.

Jacob-Jan Haaksma, J Prathap Kaniraj, Wiktoria M Opielak, June van Egmond, C Maurits de Roo, Wesley R Browne, Adriaan J Minnaard, Martin D Witte

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jacob-Jan HaaksmaStratingh Institute for Chemistry, University of Groningen, 9747 AG, Groningen, The Netherlands.ORCID https://orcid.org/0009-0006-3663-7179
J Prathap KanirajStratingh Institute for Chemistry, University of Groningen, 9747 AG, Groningen, The Netherlands.
Wiktoria M OpielakStratingh Institute for Chemistry, University of Groningen, 9747 AG, Groningen, The Netherlands.ORCID https://orcid.org/0009-0008-1349-697X
June van EgmondStratingh Institute for Chemistry, University of Groningen, 9747 AG, Groningen, The Netherlands.ORCID https://orcid.org/0009-0004-5533-9770
C Maurits de RooStratingh Institute for Chemistry, University of Groningen, 9747 AG, Groningen, The Netherlands.
Wesley R BrowneStratingh Institute for Chemistry, University of Groningen, 9747 AG, Groningen, The Netherlands.ORCID https://orcid.org/0000-0001-5063-6961
Adriaan J MinnaardStratingh Institute for Chemistry, University of Groningen, 9747 AG, Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-5966-1300
Martin D WitteStratingh Institute for Chemistry, University of Groningen, 9747 AG, Groningen, The Netherlands.ORCID https://orcid.org/0000-0003-4660-2974

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek
6 · The paper itself

Abstract

Functionalized carbohydrates are important in various fields, but protection-free selective functionalization often remains challenging. We demonstrate that the primary hydroxy group in minimally protected carbohydrates can be directly converted into a nitrile group with TEMPO, PIDA, and ammonium acetate. Both nitrile hexopyranoses and nitrile pentofuranoses are obtained and subsequent derivatizations of the nitrile group to other versatile functional groups are demonstrated. Combined evidence from literature and in-situ reaction progress monitoring with Raman spectroscopy led to the proposal that iminoiodinanes derived from PIDA play an important role in the mechanism of ammoxidation.

Indexed as

ammoxidationnitrile sugarssite‐selective modificationunprotected carbohydrates

Identifiers

PMID40178924
PMCPMC12089893

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.