Evidence map›Paper›PMID 40178915›Full record

ArticleThe Journal of clinical investigation2025

Immune repertoire profiling uncovers pervasive T cell clonal expansions in benign prostatic hyperplasia.

Anna S Pollack, Christian A Kunder, Chandler C Ho, Josephine Chou, Andrew J Pollack, Rachel Lp Geisick, Bing M Zhang, Robert B West, James D Brooks, Jonathan R Pollack

Abstract read
In one paragraph

Article in The Journal of clinical investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anna S PollackDepartment of Pathology, and.
Christian A KunderDepartment of Pathology, and.
Chandler C HoDepartment of Pathology, and.
Josephine ChouDepartment of Pathology, and.
Andrew J PollackDepartment of Pathology, and.
Rachel Lp GeisickDepartment of Pathology, and.
Bing M ZhangDepartment of Pathology, and.
Robert B WestDepartment of Pathology, and.
James D BrooksDepartment of Urology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California, USA.
Jonathan R PollackDepartment of Pathology, and.

Funding

Stanford O'Brien Urology Research CenterU54DK130065 · NIDDK · STANFORD UNIVERSITY · PI JAMES D. BROOKS · 2021 to 2026
$8.3M
NIDDK NIH HHS U54 DK130065
6 · The paper itself

Abstract

We discovered T-cell clonal expansions in benign prostatic hyperplasia, indicative of a specific adaptive immune response and with implications for disease pathogenesis and new treatments.

Indexed as

Prostatic HyperplasiaT-LymphocytesAgedClone CellsHumansMaleMiddle AgedImmunologyInflammationProstate cancerReproductive biologyT cellsUrology

Identifiers

PMID40178915
PMCPMC12126242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.