Evidence map›Paper›PMID 40178877›Full record

ArticleOrganic letters2025

The Pursuit of a Hydroxylation Switch Uncovers a Key Residue for Various Product Outcomes in the

Yujiao Li, Yiting Mei, Mark Schmidt-Dannert, Yaxin Lv, Reuben J Peters, Meirong Jia

Abstract read
In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yujiao LiState Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC Key Laboratory of Biosynthesis of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100006, China.
Yiting MeiState Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC Key Laboratory of Biosynthesis of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100006, China.
Mark Schmidt-DannertRoy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University, Ames, Iowa 50011, United States.
Yaxin LvState Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC Key Laboratory of Biosynthesis of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100006, China.
Reuben J PetersRoy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University, Ames, Iowa 50011, United States.ORCID 0000-0003-4691-8477
Meirong JiaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC Key Laboratory of Biosynthesis of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100006, China.ORCID 0000-0002-7397-5074

Funding

Purchase of replacement GC-MS for Peters R35/MIRA (GM131885)R35GM131885 · NIGMS · IOWA STATE UNIVERSITY · PI PETERS, REUBEN JOHN · 2019 to 2023
$2.6M
Investigating labdane-related diterpenoid biosynthesisR35GM156300 · NIGMS · IOWA STATE UNIVERSITY · PI REUBEN JOHN PETERS · 2025 to 2026
$803k
NIGMS NIH HHS R35 GM131885NIGMS NIH HHS R35 GM156300
6 · The paper itself

Abstract

A single residue switch leading to hydroxylation has been identified in

Indexed as

Alkyl and Aryl TransferasesBradyrhizobiumGibberellinsHydroxylationMolecular StructureAlkyl and Aryl TransferasesGibberellins

Identifiers

PMID40178877
PMCPMC12419867

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.