Evidence map›Paper›PMID 40178761›Full record

ArticleOphthalmology and therapy2025

Therapeutic Keratopigmentation: Cosmetic and Functional Outcomes.

Seyed Javad Hashemian, Sepehr Roozdar, Jorge L Alió

Abstract read
In one paragraph

Article in Ophthalmology and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. An updated comprehensive review on keratopigmentation.International journal of ophthalmology · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Seyed Javad HashemianEye Research Center, The Five Senses Health Institute, Iran University of Medical Sciences, Tehran, Iran.
Sepehr RoozdarEye Research Center, The Five Senses Health Institute, Iran University of Medical Sciences, Tehran, Iran.
Jorge L AlióVissum Miranza, Alicante, Spain. jlalio@vissum.com.ORCID http://orcid.org/0000-0002-8082-1751

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis work aimed to assess the safety and outcomes of femtosecond laser-assisted intrastromal keratopigmentation (FIK) and superficial automated keratopigmentation (SAK) using micronized mineral pigments (MMPs) as a therapeutic cosmetic tool.

methodsKeratopigmentation (KTP) was performed in 85 eyes of 85 patients with moderate-to-severe cosmetic disabilities (20/80 to no light perception) related to various etiologies causing corneal scarring or iris abnormalities. Thirty-six eyes were treated by FIK, 46 eyes by SAK, and three eyes using combined SAK + FIK. The cosmetic outcome, patient satisfaction, and occurrence of any related complications were recorded. The cosmetic or visual outcome was assessed through patient-reported feedback, while an independent observer evaluated the cosmetic appearance at the 6th month postoperatively. The mean follow-up period was 13.06 ± 9.9 months (6-53 months).

resultsThe study included 48 males and 37 females. The mean age was 37.8 ± 14.25 (14-77 years). An independent observer assessed the cosmetic outcome as excellent or good in 91.8% of cases. Excellent or good cosmetic outcome was reported by the independent observer in 91.4% of the SAK group, 91.5% of the FIK group, and 100% of SAK + FIK combined. Eighty percent of patients reported cosmetic satisfaction 3 weeks postoperative; 73.9% of SAK group, 86% of FIK group, and 100% of the combined SAK + FIK group were satisfied with their cosmetic outcome. Twelve eyes of SAK and five eyes of FIK group required additional KTP procedures because of color fading and cosmetic unsatisfaction. Post-operative symptoms were photophobia (28.2%), tearing (23.5%), and pain (8.2%). Post-operative complications were dry eye (5.8%), delayed epithelial healing (2.3%), and microbial keratitis (1.1%).

conclusionsThis study confirms that FIK and SAK using micronized mineral pigments are safe and efficient surgical techniques for managing cosmetic and visual disabilities caused by iris abnormalities and cosmetic issues related to corneal scars.

Indexed as

Corneal scarCorneal tattooFemtosecond laserIris defectKeratopigmentationMicronized mineral pigmentsReconstructive eye surgery

Identifiers

PMID40178761
PMCPMC12006568

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.