Evidence map›Paper›PMID 40178736›Full record

Observational studyInternal and emergency medicine2025

Long-term left ventricular thrombosis resolution in patients receiving vitamin k antagonists: a multicenter observational study.

Emanuele Valeriani, Giulia Astorri, Arianna Pannunzio, Daniele Pastori, Ilaria Maria Palumbo, Danilo Menichelli, Marco Paolo Donadini, Davide Santagata, Katarzyna Satula, Erica De Candia and 10 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Internal and emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Article
  4. Left Ventricular Thrombus in Oncology Patients and Beyond: Imaging, Treatment Choices, and Duration.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Emanuele Valeriani *Department of General Surgery and Surgical Specialty Paride Stefanini, Sapienza University of Rome, Rome, Italy. emanuele.valeriani@uniroma1.it.ORCID 0000-0001-9729-3214
Giulia Astorri *Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Arianna Pannunzio *Department of General Surgery and Surgical Specialty Paride Stefanini, Sapienza University of Rome, Rome, Italy.
Daniele PastoriDepartment of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Ilaria Maria PalumboDepartment of General Surgery and Surgical Specialty Paride Stefanini, Sapienza University of Rome, Rome, Italy.
Danilo MenichelliDepartment of General Surgery and Surgical Specialty Paride Stefanini, Sapienza University of Rome, Rome, Italy.
Marco Paolo DonadiniDepartment of Medicine and Surgery, University of Insubria, Varese, Italy.
Davide SantagataDepartment of Medicine and Surgery, University of Insubria, Varese, Italy.
Katarzyna SatulaInternal Vascular and Emergency Medicine - Stroke Unit, University of Perugia, Perugia, Italy.
Erica De CandiaDepartment of Diagnostic Imaging, Radiotherapy, Oncology and Haematology, Hemorrhagic and Thrombotic Diseases Center, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Luca D'InnocenzoDepartment of Diagnostic Imaging, Radiotherapy, Oncology and Haematology, Hemorrhagic and Thrombotic Diseases Center, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Antonella TufanoDepartment of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.
Rossella MarcucciDepartment of Clinical and Experimental Medicine, University of Florence and Careggi Hospital, Florence, Italy.
Martina BerteottiDepartment of Clinical and Experimental Medicine, University of Florence and Careggi Hospital, Florence, Italy.
Antonio ChistoliniHematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Francesco DragoniHematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Tommaso BucciDepartment of General Surgery and Surgical Specialty Paride Stefanini, Sapienza University of Rome, Rome, Italy.
Walter Ageno *Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Cecilia Becattini *Internal Vascular and Emergency Medicine - Stroke Unit, University of Perugia, Perugia, Italy.
Pasquale Pignatelli *Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Optimal duration of anticoagulant therapy for left ventricular thrombous (LVT) is unclear. The aim of this study is to evaluate effectiveness and safety of vitamin K antagonists (VKAs) up to 12 months in patients with LVT. Patients diagnosed with LVT between 2011 and 2023 and treated with VKAs until LVT resolution or up to 12 months were enrolled in a retrospective cohort study. Primary outcome included on-treatment LVT resolution, secondary outcomes acute ischemic stroke, myocardial infarction, peripheral embolism, and major and clinically relevant non-major bleedings during the 12-month follow-up. Ninety patients were included. Median age was 66 years and 78.9% were male. Mean time in therapeutic range was 61% and 32.9% of patients received VKA monotherapy, with the remaining concomitant antiplatelet treatment. The 3, 6, 12 months cumulative incidences of LVT resolution were 27% (95% confidence intervals -95%CI-, 18%-36%), 47% (95%CI 36%-57%), and 70% (95% CI 60%-79%), respectively. At Cox regression model, reduced left ventricular ejection fraction (Hazard Ratio 0.48; 95%CI 0.24-0.95) and left-ventricular aneurysms (Hazard Ratio 0.44; 95%CI 0.22-0.88) were associated with reduced LVT resolution. One patient developed an acute ischemic stroke and one an acute myocardial infarction. Two patients developed a major and four a clinically relevant non-major bleeding. Incidence of LVT resolution appeared to be higher at 12 than at 3 and 6 months of follow-up, and the rates of on-treatment acute arterial and bleeding events were low. Reduced left ventricular ejection fraction and left-ventricular aneurysm appeared to be associated with a lower rates of LVT resolution.

Indexed as

AnticoagulantsHeart VentriclesThrombosisVitamin KAgedCohort StudiesFemaleHumansMaleMiddle AgedRetrospective StudiesAnticoagulantsVitamin KAcenocoumarolAnticoagulantsHeparinVenous thromboembolismWarfarin

Identifiers

PMID40178736
PMCPMC12130138

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.