ArticleOral radiology2025
Bone alterations in head and neck pleomorphic adenoma: Scoping review.
Article in Oral radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Imaging features of lacrimal gland disease.Frontiers in ophthalmology · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesBone destruction adjacent to salivary gland tumors has been regarded as an indirect sign of malignancy. This scoping review explores possible bone changes due to head and neck pleomorphic adenoma and identifies risk factors for bone destruction.
methodsArticles on bone alterations in head and neck pleomorphic adenoma were searched online using PubMed, Scopus and Scholar, according to PRISMA-ScR guidelines. Only histopathologically confirmed pleomorphic adenomas were included. Extracted data were age, gender, location and size of tumor, duration of symptoms, type of bone erosion and recurrency status.
resultsThe search resulted in 145 pleomorphic adenomas with adjacent bone alterations. The majority caused expansile bone changes, such as cortex erosion (61.4%) and scalloping (31.0%). Extensive bone destruction was reported in 11 cases (full thickness erosion in 3.4% and bone marrow invasion in 4.1%). Significant risk factors for aggressive bone destruction were tumor size and duration of symptoms (OR = 1.08; 95% CI 1.02-1.14 and OR = 1.03; 95% CI 1.00-1.05).
conclusionsAlthough mostly bone erosion or scalloping is observed, larger or longstanding pleomorphic adenomas have the capacity of developing more extensive bone destruction, without malignant transformation. However, bone destruction is very rare in pleomorphic adenoma and more likely indicates the presence of malignancy.
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