Evidence map›Paper›PMID 40178679›Full record

Trial reportClinical rheumatology2025

Prospective Sham-Controlled trial: acupuncture for symptom-relieving in patients with Sjögren's disease.

Jaciara M Gomes-Silva, Carolina P Torres, Lucas R Teixeira, Maria da Conceição P Saraiva, Fabiola R Oliveira, Eduardo M Rocha, Maria Cristina Borsatto, Ana Carolina F Motta

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04056221 (Effects of Acupuncture on Xerostomia and Xerophthalmia in Sjögren's Syndrome), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04056221 nacompletednot on this map

Effects of Acupuncture on Xerostomia and Xerophthalmia in Sjögren's Syndrome: a Randomized, Double-blinded Clinical Trial

TypeinterventionalSponsorAna Carolina Fragoso Motta, DDS, PhDRan2019 to 2022Enrolled50ConditionsSjogren's SyndromeArmsAcupuncture, Sham acupuncture
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jaciara M Gomes-SilvaDepartment of Pediatric Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo, Ribeirão Preto, Brazil.ORCID http://orcid.org/0000-0003-1605-5551
Carolina P TorresDepartment of Pediatric Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo, Ribeirão Preto, Brazil.ORCID http://orcid.org/0000-0003-3924-4494
Lucas R TeixeiraDepartment of Pathology and Forensic Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.ORCID http://orcid.org/0000-0002-3563-9379
Maria da Conceição P SaraivaDepartment of Pediatric Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo, Ribeirão Preto, Brazil.ORCID http://orcid.org/0000-0001-6858-7029
Fabiola R OliveiraRibeirão Preto Medical School, University Hospital, Ribeirão Preto, Brazil.ORCID http://orcid.org/0000-0002-9196-7422
Eduardo M RochaDepartment of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.ORCID http://orcid.org/0000-0001-9888-7313
Maria Cristina Borsatto *Department of Pediatric Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo, Ribeirão Preto, Brazil.ORCID http://orcid.org/0000-0003-1386-1590
Ana Carolina F Motta *Department of Stomatology, Public Health and Forensic Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo, Av. Do Café, S/N, Ribeirão Preto, São Paulo, CEP: 14040-904, Brazil. anacfm@usp.br.ORCID http://orcid.org/0000-0002-3887-9239

Funding

Fundação de Amparo à Pesquisa do Estado da Bahia 2015/07249-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/23211-0Research Core of Ocular Physiopathology and Therapeutics at the University of São Paulo (NAP-FTO) 12.1.25431.01.7
6 · The paper itself

Abstract

objectiveThis study aimed to assess the clinical efficacy of acupuncture in relieving sicca symptoms of SjD.

methodsA prospective, single-center, randomized, double-blind, controlled trial was conducted on SjD patients experiencing dry eyes and dry mouth. Forty-six patients were randomized and 27 completed the study (acupuncture, n = 15; sham, n = 12). Patients received either acupuncture or sham acupuncture (control) weekly for 8 weeks. Key outcomes, including Schirmer test (ST), corneal fluorescein staining score, tear film break-up time, Ocular Surface Disease Index, unstimulated whole salivary flow (UWSF), EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI), Xerostomia Inventory (XI) score, Oral Health Impact Profile (OHIP-14) score, and Challacombe scale, were measured at baseline, immediately after treatment, and 4 weeks later. Statistical analysis consisted of comparing outcomes between groups over time.

resultsThe acupuncture group exhibited significant improvement in total ESSPRI and ESSPRI dryness scores. The positive effects persisted for at least 4 weeks after the completion of treatment. Furthermore, the acupuncture group exhibited improvement over time in the ESSPRI fatigue domain, ESSPRI pain domain, OHIP-14, XI, UWSF, and ST. No other statistically significant differences were observed.

conclusionAcupuncture is effective in relieving dryness in SjD patients. Larger samples and longer observation periods are necessary to better understand the effectiveness of this intervention in SjD. (NCT04056221/ 18/02/2019). Key Points • Acupuncture is a low-cost method with few side effects • Acupuncture exerts a symptom-relieving effect in primary Sjögren's disease patients.

Indexed as

Acupuncture TherapySjogren's SyndromeXerostomiaAdultAgedDouble-Blind MethodDry Eye SyndromesFemaleHumansMaleMiddle AgedProspective StudiesTreatment OutcomeAcupunctureQuality of lifeSjögren’s diseaseXerophthalmiaXerostomia

Identifiers

PMID40178679

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.