Evidence map›Paper›PMID 40178667›Full record

ArticleMarine biotechnology (New York, N.Y.)2025

Terpenoids with Antiangiogenic Activity from Formosan Soft Coral Caementabunda hypotentaculata.

Hsin Huang, Chen-Yu Yang, Shih-Wei Wang, Limbadri Salendra, Shu-Rong Chen, Tzi-Yi Ke, Yu-Liang Yang, Yu-Chi Lin, Yuan-Bin Cheng

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Article in Marine biotechnology (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hsin Huang *Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Chen-Yu Yang *Division of Pediatric Orthopedics, Department of Orthopedic Surgery, MacKay Memorial Hospital, Taipei, Taiwan.
Shih-Wei WangGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
Limbadri SalendraDepartment of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Shu-Rong ChenDepartment of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Tzi-Yi KeDepartment of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Yu-Liang YangDepartment of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Yu-Chi LinNational Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, Taiwan.
Yuan-Bin ChengDepartment of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan. jmb@mail.nsysu.edu.tw.ORCID http://orcid.org/0000-0001-6581-1320

Funding

National Science and Technology Council NSTC 112-2628-B-110-005
6 · The paper itself

Abstract

Soft corals of the genus Caementabunda (synonym Cespitularia) were reported to possess terpenoids with various carbon skeletons. In this research, samples of C. hypotentaculata were collected before and after spawning (in May and August) to compare their secondary metabolites. With the aid of LC-MS/MS molecule networking, a series of unknown verticillane-type diterpenoids were targeted. After repeated column chromatography, five new verticillane-type diterpenoids (1‒5) and one new eudesmanolide-type sesquiterpenoid (6), together with twenty-four known compounds (7‒30), were identified from the Formosan soft coral C. hypotentaculata. Their structures were determined by UV, IR, MS, and NMR analyses, together with the biogenetic considerations of terpenoids. Our pharmacological study showed that the ethanol extract of C. hypotentaculata exhibited antiangiogenic potential against human endothelial progenitor cells. Among all isolated compounds, compound 30 demonstrated a moderate antiangiogenic effect with an IC

Indexed as

Angiogenesis InhibitorsAnthozoaTerpenesAnimalsDiterpenesHumansTandem Mass SpectrometryAngiogenesis InhibitorsDiterpenesTerpenesAnti-angiogenesisCaementabunda hypotentaculataMolecule networkingSoft coralTerpenoids

Identifiers

PMID40178667

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.