Evidence map›Paper›PMID 40178656›Full record

ArticleInflammation2025

CRISPR/Cas9-Mediated Knockout and Overexpression Studies Unveil the Role of PD-L1 in Immune Modulation in a Psoriasis-like Mouse Model.

Chunjie Gao, Yunxi Cai, Xinxin Wu, Jiankun Song, Qi Zheng, Mingxia Wang, Ying Luo, Yue Luo, Xiaoya Fei, Ying Zhang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Chunjie Gao *Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China.
Yunxi Cai *Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China.
Xinxin Wu *Shanghai Skin Disease Hospital, Institute of Dermatology, School of Medicine, Tongji University, Shanghai, 200443, China.
Jiankun SongShanghai Skin Disease Hospital, Institute of Dermatology, School of Medicine, Tongji University, Shanghai, 200443, China.
Qi ZhengShanghai Skin Disease Hospital, Institute of Dermatology, School of Medicine, Tongji University, Shanghai, 200443, China.
Mingxia WangShanghai Skin Disease Hospital, Institute of Dermatology, School of Medicine, Tongji University, Shanghai, 200443, China.
Ying LuoDepartment of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China.
Yue LuoShanghai Skin Disease Hospital, Institute of Dermatology, School of Medicine, Tongji University, Shanghai, 200443, China.
Xiaoya FeiShanghai Skin Disease Hospital, Institute of Dermatology, School of Medicine, Tongji University, Shanghai, 200443, China.
Ying ZhangShanghai Skin Disease Hospital, Institute of Dermatology, School of Medicine, Tongji University, Shanghai, 200443, China.
Yang YangShanghai Skin Disease Hospital, Institute of Dermatology, School of Medicine, Tongji University, Shanghai, 200443, China.
Le KuaiDepartment of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China.
Yi RuShanghai Skin Disease Hospital, Institute of Dermatology, School of Medicine, Tongji University, Shanghai, 200443, China.
Seokgyeong HongDepartment of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China.
Na TianDepartment of Rheumatology and Immunology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. arrow_tn@163.com.
Bin LiShanghai Skin Disease Hospital, Institute of Dermatology, School of Medicine, Tongji University, Shanghai, 200443, China. 18930568129@163.com.
Zhan ZhangDepartment of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China. 986034931@qq.com.

Funding

Clinical Transformation Incubation Program in Hospital lczh2021-05, lcfy2022-04, lczh2023-01Evidence-based dermatology base sponsored by State Administration of Traditional Chinese Medicine, High-level Chinese Medicine Key Discipline Construction Project (Integrative Chinese and Western Medicine Clinic) of National Administration of TCM zyyzdxk-2023065Shanghai Dermatology Hospital Demonstration Research Ward Project SHDC2023CRW009Shanghai Dermatology Research Center 2023ZZ02017Shanghai Key Discipline Construction Project of Traditional Chinese Medicine shzyyzdxk-2024104Shanghai Municipal Health Commission Health Industry Clinical Research Special Project 20224Y0373, 20234Y0269, 20234Y0075Shanghai Municipal Health Commission Health Industry Clinical Research Special Project No. 82174383, 82204954, 82304819, 82305232, 82374458, W2433194Shanghai Science and Technology Development Funds (Sailing Program) 22YF1441300Youth Medical Talents-Specialist Program of Shanghai "Rising Stars of Medical Talents" Youth Development Program, and Youth Talent Promotion Project of China Association of Traditional Chinese Medicine (2024-2026) Category B 2024-QNRC2-B04
6 · The paper itself

Abstract

The role of programmed death-ligand 1 (PD-L1), an essential immune checkpoint protein, has garnered considerable interest in recent years due to its influence on immune responses, particularly inhibiting immature Th cells into Th17 cells. This study aims to examine the effect of PD-L1 on psoriasis progress, which is the condition characterized by an immune response dominated by Th17 cells. We constructed the PD-L1 knockout (PD-L1

Indexed as

B7-H1 AntigenCRISPR-Cas SystemsPsoriasisAnimalsDisease Models, AnimalImiquimodMiceMice, KnockoutB7-H1 AntigenCd274 protein, mouseImiquimodCRISPR/Cas9 technologyPD-L1PsoriasisTh17 cellsThe mouse model

Identifiers

PMID40178656
PMCPMC12596319

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.