Evidence map›Paper›PMID 40178606›Full record

ReviewAnnals of hematology2025

Radiotherapy alone with curative intent in a case of limited-stage extranodal NK/T-cell lymphoma nasal type: a case report and review of the literature.

Biancamaria Mandelli, Donatella Caivano, Antonella Fontana, Natalia Cenfra, Sergio Mecarocci, Maristella Marrocco, David Fanciullo, Roberta Mazzarella, Martina Lorenzon, Giada Pacitto and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Biancamaria MandelliHematology Unit, Department of Translational and Precision Medicine, Policlinico Umberto I, Sapienza University, Rome, Italy. biancamaria.mandelli@uniroma1.it.
Donatella CaivanoDepartment of Oncology Radiation Therapy, San Giovanni Addolorata Hospital, Rome, Italy.
Antonella FontanaDepartment of Oncology Radiation Therapy, S.M. Goretti Hospital, Latina, Italy.
Natalia CenfraDepartment of Hematology, S.M. Goretti Hospital, Polo Universitario Pontino, Sapienza Univesity, Latina, Italy.
Sergio MecarocciDepartment of Hematology, S.M. Goretti Hospital, Polo Universitario Pontino, Sapienza Univesity, Latina, Italy.
Maristella MarroccoMedical Physics Unit, S.M. Goretti Hospital, Latina, Italy.
David FanciulloHematology Unit, Department of Translational and Precision Medicine, Policlinico Umberto I, Sapienza University, Rome, Italy.
Roberta MazzarellaHematology Unit, Department of Translational and Precision Medicine, Policlinico Umberto I, Sapienza University, Rome, Italy.
Martina LorenzonHematology Unit, Department of Translational and Precision Medicine, Policlinico Umberto I, Sapienza University, Rome, Italy.
Giada PacittoHematology Unit, Department of Translational and Precision Medicine, Policlinico Umberto I, Sapienza University, Rome, Italy.
Alessandro PulsoniDepartment of Hematology, S.M. Goretti Hospital, Polo Universitario Pontino, Sapienza Univesity, Latina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT), is an aggressive malignancy primarily affecting the sinonasal region, with a strong association with Epstein-Barr virus (EBV) infection. The disease is significantly more prevalent in Asian and Latin American populations. Diagnosis is particularly challenging in nonendemic regions. We present the case of a 78-year-old male with a one-year history of nasal lesions, later diagnosed with ENKTCL-NT. The patient was treated with curative-intent radiotherapy, achieving a complete clinical response. Radiation therapy, particularly utilizing advanced techniques such as Volumetric Modulated Arc Therapy (VMAT), resulted in favorable outcomes with minimal toxicity. This case emphasizes the importance of early diagnosis, accurate staging, and personalized radiotherapy in the management of ENKTCL-NT. Ongoing research into the molecular pathogenesis, treatment strategies, and prognostic factors is crucial for improving outcomes, particularly in advanced-stage disease.

Indexed as

Lymphoma, Extranodal NK-T-CellNose NeoplasmsRadiotherapy, Intensity-ModulatedAgedEpstein-Barr Virus InfectionsHumansMaleNeoplasm StagingEarly diagnosisEpstein-Barr virusExtranodal NK/T-cell lymphomaNasal typePersonalized treatmentRadiotherapyVolumetric modulated arc therapy

Identifiers

PMID40178606
PMCPMC12141148

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.