Evidence map›Paper›PMID 40178600›Full record

ReviewGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2025

Persistent avascular retina in retinopathy of prematurity.

Ting Fang Tan, Su Ann Tay, Swati Agarwal-Sinha, Gavin Siew Wei Tan, Wei-Chi Wu, Andrew S H Tsai

Abstract readReview
PubMed Publisher
In one paragraph

Review in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ting Fang TanSingapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.
Su Ann TaySingapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.
Swati Agarwal-SinhaRetina Consultants of Nevada, Las Vegas, United States.
Gavin Siew Wei TanSingapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.
Wei-Chi WuDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan.
Andrew S H TsaiSingapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore. mr.andrewt@gmail.com.ORCID http://orcid.org/0000-0002-2887-3597

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persistent avascular retina (PAR) has been increasingly reported with the increased use of anti-vascular endothelial growth factor (VEGF) agents in treatment-requiring ROP. However, they have also been observed in ROP eyes that did not meet treatment requirement and spontaneously regressed. PAR is highlighted in the updated nomenclature under the International Classification of Retinopathy of Prematurity, 3rd edition (ICROP3) consensus statement, underscoring the increased emphasis in detecting PAR. PAR has been noted to persist beyond existing ROP screening guidelines, and were found to be associated with complications like retinal tear and detachment, especially in eyes with more posterior PAR. Thus, serial monitoring of retinal vascularization, facilitated by fluorescein angiography and wide-field imaging, for these associated complications have been encouraged. The current lack of consensus in the follow-up and management of PAR prompts further work in this area: understanding the natural course of retinal vascularization in both untreated and treated ROP, the modulation of anti-VEGF on retinal function, and the clinical significance of PAR-associated vascular patterns can help to guide management protocols for PAR in ROP eyes.

Indexed as

Retinal VesselsRetinopathy of PrematurityAngiogenesis InhibitorsFluorescein AngiographyFundus OculiGestational AgeHumansInfant, NewbornVascular Endothelial Growth Factor AAngiogenesis InhibitorsVascular Endothelial Growth Factor AAnti-vascular endothelial growth factor injectionsPersistent avascular retinopathyRetinopathy of prematuritySpontaneous regression

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.