ArticleEuropean journal of applied physiology2025
Complications of applying approximate entropy to heart rate variability to locate optimal complexity in children with attention deficit hyperactivity disorder.
Article in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionThe aim is to scrutinize approximate entropy (ApEn) to distinguish optimal complexity of heart rate variability (HRV) in children diagnosed with attention deficit hyperactivity disorder (ADHD). This was accomplished by varying their embedding dimension m and tolerance r. Determination of optimal m and r is heuristic. ApEn was enforced in ADHD to assess its effects on the HRV chaotic response.
methodsWe studied 56 children divided equally into two groups: ADHD and control. Autonomic modulation of the heart rate was monitored for 20 min in the supine position without any physical, sensory or pharmacological stimuli. ApEn initially had r: 0.1 → 1.0 in 0.1 intervals and m: 1 → 10 in intervals of 1. The statistical significances were measured by three effect sizes: Cohen's d, Hedges' g and Glass's Δ.
resultsThose most statistically important were for r = 0.9334, and m = 1, 2 and 3. Cohen's d (1.1277; m = 2) and Hedges' g (1.1119; m = 2) are the most reliable effect sizes. Glass's Δ (1.3724; m = 1) is unfortunately less reliable. ROC curve analysis shows AUC > 0.77 for r = 0.9334 and m = 1, 2, and 3.
conclusionApEn recognized the increased chaotic response in ADHD. This was confirmed by three effect sizes, AUC and p value during ROC analysis. Still, ApEn is an unreliable mathematical marker. ADHD discrimination was only achieved by extending the surveillance ranges for r; 0.8 → 1.0 and m; 1 → 3 at intervals of 0.0167. This necessitates an 'a priori' study making it inapt for online analysis. Even so, it could be useful in 'post hoc' analysis.
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