Evidence map›Paper›PMID 40178545›Full record

ArticleInternational urogynecology journal2025

Platelet-Rich Plasma and Fractional CO

Nadia Willison, Connor McPhail, Elvis Seman, Mahshid Taheri, Pouria Aryan, Tran Nguyen, Johnny Yi, Derek Abbott, Tanaka Dune, Fariba Behnia-Willison

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International urogynecology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07414849 (The Amper Study), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07414849 narecruitingnot on this mapstarted 2026, after this paper: background citation

The Amper Study: Amniotic Membrane for the Prevention of Mesh Exposure in Vaginal Reconstructive Surgery

TypeinterventionalSponsorHospital General de Agudos J. M. PennaRan2026 to 2028Enrolled330ConditionsPelvic Organ Prolapse Vaginal Surgery, Stress Urinary Incontinence in WomenArmsSacrospinous Hysteropexy with Mesh, Retropubic Mid-urethral Sling (Bottom-Up), Transobturator Mid-urethral Sling (Out-In)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nadia WillisonDiscipline of Biomedical Engineering, School of EME, The University of Adelaide, Adelaide, South Australia, Australia. nadia.willison@adelaide.edu.au.ORCID 0009-0004-3570-2499
Connor McPhailFlinders Medical Centre, Flinders University, Bedford Park, South Australia, Australia.
Elvis SemanFlinders Medical Centre, Flinders University, Bedford Park, South Australia, Australia.
Mahshid TaheriFBW Gynaecology Plus, Ashford, South Australia, Australia.
Pouria AryanDiscipline of Biomedical Engineering, School of EME, The University of Adelaide, Adelaide, South Australia, Australia.
Tran NguyenDiscipline of Biomedical Engineering, School of EME, The University of Adelaide, Adelaide, South Australia, Australia.
Johnny YiDepartment of Medical and Surgical Gynecology, Mayo Clinic, Phoenix, Arizona, USA.
Derek AbbottDiscipline of Biomedical Engineering, School of EME, The University of Adelaide, Adelaide, South Australia, Australia.
Tanaka DuneFlinders Medical Centre, Flinders University, Bedford Park, South Australia, Australia.
Fariba Behnia-WillisonDiscipline of Biomedical Engineering, School of EME, The University of Adelaide, Adelaide, South Australia, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction and hypothesisMesh implants were used in Australia until 2018 for managing pelvic organ prolapse. Owing to complications such as dyspareunia, mesh exposure, erosion and vaginal discharge, transvaginal mesh was removed from the market. Regenerative treatments such as transvaginal platelet-rich plasma (PRP) and fractional CO

methodsFrom 2013 to 2024, women with mesh complications, including dyspareunia, vaginal discharge and/or vaginal mesh exposure (< 2 cm) awaiting surgery, were enrolled in this prospective study. Wilcoxon signed-rank test was used to assess IQR changes in Australian Pelvic Floor Questionnaire (APFQ) and Pelvic Organ Prolapse Quantification symptom severity, whereas a general linear model analysed outcome differences at baseline, 3-6 months and > 9 months. The primary aim was to assess the proportion of patients who avoided surgical intervention after PRP and CO

resultsA cohort of 47 women were eligible. The average age and body mass index were 64 years and 27.94 kg/m

conclusionsPlatelet-rich plasma and CO

Indexed as

Lasers, GasLaser TherapyPelvic Organ ProlapsePlatelet-Rich PlasmaPostoperative ComplicationsSurgical MeshAgedDyspareuniaFemaleHumansMiddle AgedProspective StudiesTreatment OutcomeVaginaCO2 laserPelvic organ prolapsePlatelet-rich plasmaVaginal meshVaginal mesh complicationsVaginal mesh exposure

Identifiers

PMID40178545
PMCPMC12064601

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.