Evidence map›Paper›PMID 40178516›Full record

ArticleeLife2025

Neuroprotective role of Hippo signaling by microtubule stability control in

Hanee Lee, Junsu Kang, Sang-Hee Lee, Dowoon Lee, Christine H Chung, Junho Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. eNeuro · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hanee LeeDepartment of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0003-1511-5997
Junsu KangDepartment of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0001-5286-5426
Sang-Hee LeeDepartment of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Republic of Korea.
Dowoon LeeDepartment of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Republic of Korea.
Christine H ChungDepartment of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Republic of Korea.
Junho LeeDepartment of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-6421-1195

Funding

National Research Foundation of Korea 2019R1A6A1A10073437Samsung Science and Technology Foundation SSTF-BA1501-52
6 · The paper itself

Abstract

The evolutionarily conserved Hippo (Hpo) pathway has been shown to impact early development and tumorigenesis by governing cell proliferation and apoptosis. However, its post-developmental roles are relatively unexplored. Here, we demonstrate its roles in post-mitotic cells by showing that defective Hpo signaling accelerates age-associated structural and functional decline of neurons in

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsMicrotubulesNeuroprotectionProtein Serine-Threonine KinasesSignal TransductionAnimalsHippo Signaling PathwayNeuronsCaenorhabditis elegans ProteinsProtein Serine-Threonine KinasesC. elegansdevelopmental biologyHippomicrotubuleneuronal aging

Identifiers

PMID40178516
PMCPMC11968107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.