Evidence map›Paper›PMID 40178503›Full record

ArticleFuture microbiology2025

Does

Izabel Almeida Alves, Keli Jaqueline Staudt, Bruna Gaelzer Silva Torres, Calinca Elioterio Oliveira, Ryan Lago Araujo Rieper, Layza Kowalski, Bibiana Verlindo de Araújo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Izabel Almeida AlvesFaculdade de Farmácia, Departamento do Medicamento, Universidade Federal da Bahia, Salvador, Bahia, Brasil.
Keli Jaqueline StaudtPrograma de Pós-graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.
Bruna Gaelzer Silva TorresPrograma de Pós-graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.
Calinca Elioterio OliveiraPrograma de Pós-Graduação em Farmácia, Universidade Estadual da Bahia, Salvador, Bahia, Brasil.
Ryan Lago Araujo RieperFaculdade de Farmácia, Departamento do Medicamento, Universidade Federal da Bahia, Salvador, Bahia, Brasil.
Layza KowalskiPrograma de Pós-graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.
Bibiana Verlindo de AraújoPrograma de Pós-graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimAssessing the disseminated meningitis caused by MATERIALS &

methodsThe yeast presence was investigated in different tissues by histological and microbiological assays, and biochemical parameters such as urea, glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), creatinine, creatine kinase (CK), creatinine, albumin level, leukocyte counts, and brain vascular permeability (Evans blue test) were evaluated in healthy and infected groups. Levels of fluconazole reached in the animal's brain were determined by µD.

resultsDifferences in albumin, urea, GPT, and CK between healthy and infected animals were observed in the levels of Evans blue as well as in the brain (0.51

conclusionThe model validated presents characteristics similar to those observed in patients and can be applied to pharmacokinetic investigations.

Indexed as

Antifungal AgentsCryptococcosisCryptococcus neoformansFluconazoleMeningitis, CryptococcalAnimalsBrainDisease Models, AnimalMaleMicrodialysisRatsRats, WistarAntifungal AgentsFluconazolecryptococcosisCryptococcus neoformansdisseminated meningitismicrodialysismodels of infections

Identifiers

PMID40178503
PMCPMC11980448

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.