Evidence map›Paper›PMID 40178462›Full record

ArticleThe Journal of adolescent health : official publication of the Society for Adolescent Medicine2025

Adverse Childhood Experiences are Associated With the Timing of Puberty in Girls but Not in Boys.

Ai Kubo, Sara Aghaee, Julia Acker, Julianna Deardorff

Abstract read
In one paragraph

Article in The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Associations of In Utero Exposure to Racial Violence and Reproductive Development: The Bogalusa Heart Study.American journal of human biology : the official journal of the Human Biology Council · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ai KuboDivision of Research, Kaiser Permanente Northern California, Pleasanton, California. Electronic address: Ai.kubo@kp.org.
Sara AghaeeDivision of Research, Kaiser Permanente Northern California, Pleasanton, California.
Julia AckerSchool of Public Health, University of California, Berkeley, California.
Julianna DeardorffSchool of Public Health, University of California, Berkeley, California.

Funding

Sex and Race/Ethnicity-specific Multilevel Factors Influencing Pubertal Trajectories: a Population-based StudyR01HD098220 · NICHD · KAISER FOUNDATION RESEARCH INSTITUTE · PI KUBO, AI · 2019 to 2022
$2.5M
Understanding the Impact of Early Life Factors on Cardiometabolic Risk throughout the Life Course in a Large Population-based Cohort of Adolescents and Young Adults R01HL177516 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI Julianna Deardorff, Ai Kubo · 2025 to 2026
$1.5M
Population-based Incidence, Time Trends, and Early Life Factors Associated with Type 2 Diabetes Among Asian American, Native Hawaiian, and Pacific Islander Adolescents and Young AdultsR01DK139116 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI Ai Kubo · 2025 to 2026
$1.4M
NHLBI NIH HHS R01 HL177516NICHD NIH HHS R01 HD098220NIDDK NIH HHS R01 DK139116
6 · The paper itself

Abstract

purposeTo examine the associations between adverse childhood experiences (ACEs) scores from routine screenings in pediatric checkups and timing of puberty in a diverse cohort of adolescents.

methodsA retrospective cohort study of 52,573 pediatric members of Kaiser Permanente Northern California, an integrated healthcare delivery system. Exposure was the total ACEs score, determined using caregiver- and self-reported scores across all well-child visits, and categorized into 0, 1-3, 4-6, or 7-10 ACEs. Outcomes were age at menarche and pubertal onset, using physician-assessed Sexual Maturity Ratings.

resultsGirls with ACEs had a substantially higher risk of earlier menarche and pubertal onset compared to those without ACEs. There were no associations between ACEs and boys' pubertal timing. DISCUSSION: These results highlight the importance of screening for ACEs in a clinical setting to address adolescents' psychological well-being and healthy lifestyle habits, which in turn may prevent adverse health outcomes associated with early puberty.

Indexed as

Adverse Childhood ExperiencesPubertyAdolescentCaliforniaChildFemaleHumansMaleMenarcheRetrospective StudiesSex FactorsAdolescenceAdverse childhood experiences (ACEs)AdversityGonadarcheMenarchePubarchePubertal timingPubertyThelarche

Identifiers

PMID40178462
PMCPMC12162238

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.