Evidence map›Paper›PMID 40178261›Full record

ArticleAntimicrobial agents and chemotherapy2025

The antimycotic 5-fluorocytosine is a virulence inhibitor of uropathogenic

Srikanth Ravishankar, Antonietta Lucia Conte, Stacy Julisa Carrasco Aliaga, Valerio Baldelli, Karen Leth Nielsen, Moira Paroni, Maria Pia Conte, Paolo Landini, Elio Rossi

Abstract read
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In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Srikanth RavishankarDepartment of Biosciences, University of Milan, Milan, Lombardy, Italy.ORCID 0000-0002-4904-2303
Antonietta Lucia ConteDepartment of Public Health and Infectious Diseases, Sapienza University, Rome, Lazio, Italy.
Stacy Julisa Carrasco AliagaDepartment of Biosciences, University of Milan, Milan, Lombardy, Italy.ORCID 0009-0007-3551-633X
Valerio BaldelliDepartment of Biosciences, University of Milan, Milan, Lombardy, Italy.ORCID 0000-0001-6698-7061
Karen Leth NielsenDepartment of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-7912-1985
Moira ParoniDepartment of Biosciences, University of Milan, Milan, Lombardy, Italy.ORCID 0000-0001-8199-3128
Maria Pia ConteDepartment of Public Health and Infectious Diseases, Sapienza University, Rome, Lazio, Italy.ORCID 0000-0003-0753-6003
Paolo LandiniDepartment of Biosciences, University of Milan, Milan, Lombardy, Italy.ORCID 0000-0003-0999-426X
Elio RossiDepartment of Biosciences, University of Milan, Milan, Lombardy, Italy.ORCID 0000-0002-2042-608X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biofilm can enhance antibiotic tolerance in bacteria, making treatment of biofilm-associated infections in clinical settings a significant challenge. 5-Fluorocytosine (5-FC), an FDA-approved drug mostly used as an antifungal, can hinder biofilm formation and production of virulence factors in Gram-negative bacteria. In this study, we tested 5-FC on nine uropathogenic

Indexed as

biofilmcombination antimicrobial therapyurinary tract infectionsuropathogenic Escherichia colivirulence

Identifiers

PMID40178261
PMCPMC12057335

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.