Evidence map›Paper›PMID 40178246›Full record

Trial reportJournal of hypertension2025

Sex differences in blood pressure lowering of initial treatment with ultra-low dose combination therapy versus monotherapy. A secondary analysis of QUARTET.

Edel T O'Hagan, Simone L Marschner, Desi Quintans, Graham S Hillis, Emily R Atkins, Sarah Zaman, Markus P Schlaich, Anthony Rodgers, Clara K Chow

Abstract readClinical Trial, Phase IIIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Edel T O'HaganWestmead Applied Research Centre, Faculty of Medicine and Health, The University of Sydney, Australia.
Simone L MarschnerWestmead Applied Research Centre, Faculty of Medicine and Health, The University of Sydney, Australia.
Desi QuintansWestmead Applied Research Centre, Faculty of Medicine and Health, The University of Sydney, Australia.
Graham S HillisDepartment of Cardiology, Royal Perth Hospital.
Emily R AtkinsThe George Institute for Global Health, UNSW Sydney.
Sarah ZamanWestmead Applied Research Centre, Faculty of Medicine and Health, The University of Sydney, Australia.
Markus P SchlaichDobney Hypertension Centre, Medical School Royal Perth Hospital Unit, The University of Western Australia, Australia.
Anthony RodgersThe George Institute for Global Health, UNSW Sydney.
Clara K ChowWestmead Applied Research Centre, Faculty of Medicine and Health, The University of Sydney, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Women with hypertension are more likely than men to have ineffective treatment where blood pressure (BP) is treated but not controlled. The aim of this study was to investigate whether a quadpill based strategy differs between males and females. A secondary analysis of The Quadruple UltrA-low-dose tReaTment for hypErTension (QUARTET); randomized controlled trial. In this analysis the primary outcome was sex differences in unattended office systolic BP at 12 weeks. The QUARTET study recruited 591 participants (40% female) with mean age 59 (standard deviation 12) years [male 57 (12); female 62 (11)]. Males and females recorded a similar reduction in unattended systolic BP at 12 weeks with no interaction between group allocation and sex [male:mean difference (MD) in mmHg -6.95 (95% CI -9.53 to -4.38), female: MD -6.34 (95% CI -9.50 to -3.18), interaction P  = 0.77]. The quadpill strategy was similarly effective in men and women. Initiating BP control with a quadpill in women presents a promising approach to achieving similar BP control levels to men.

Indexed as

Antihypertensive AgentsBlood PressureHypertensionAgedDrug Therapy, CombinationFemaleHumansMaleMiddle AgedSecondary Data AnalysisSex FactorsAntihypertensive Agentsadherencefixed-dose combinationhigh blood pressureinertiaquadpillsafetytolerabilitywomen

Identifiers

PMID40178246
PMCPMC12144527

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.