Evidence map›Paper›PMID 40178125›Full record

ArticleA&A practice2025

Dantrolene for the Treatment of Chronic Inflammatory Demyelinating Polyneuropathy-Induced Painful Muscle Spasms: A Case Report.

Yuri Chaves Martins, Sejal V Jain, Amol M Patwardhan

Abstract readCase Reports
In one paragraph

Article in A&A practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yuri Chaves MartinsFrom the Department of Anesthesiology, Saint Louis University School of Medicine, St. Louis, Missouri.
Sejal V JainDepartment of Anesthesiology and Pain Management, The University of Texas Southwestern Medical Center, Dallas, Texas.
Amol M PatwardhanDepartment of Anesthesiology and Pain Management, The University of Texas Southwestern Medical Center, Dallas, Texas.

Funding

Validation of Spinal Neurotensin Receptor 2 as an Analgesic TargetR01NS116694 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI PATWARDHAN, AMOL M · 2020 to 2025
$2.0M
Mechanism of intrathecal Contulakin-G induced analgesia without motor blockK08NS104272 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI PATWARDHAN, AMOL M · 2018 to 2022
$987k
NINDS NIH HHS K08 NS104272NINDS NIH HHS R01 NS116694
6 · The paper itself

Abstract

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare neurological disorder that causes progressive weakness, sensory dysfunction, and often debilitating muscle spasms and pain. A man in his early 30s with a history of Hodgkin's lymphoma treated with chemotherapy developed neurologic symptoms initially misdiagnosed as chemotherapy-induced neuropathy. A diagnosis of CIDP was subsequently confirmed by nerve conduction studies. Despite treatment with muscle relaxants, benzodiazepines, botulinum toxin injections, and opioids, the patient's muscle spasms remained refractory. Dantrolene was then introduced at 25 mg orally 4 times/d, resulting in a significant reduction in the frequency and intensity of muscle spasms.

Indexed as

DantroleneMuscle Relaxants, CentralPolyradiculoneuropathy, Chronic Inflammatory DemyelinatingSpasmAdultHumansMaleDantroleneMuscle Relaxants, Central

Identifiers

PMID40178125
PMCPMC12810720

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.