Evidence map›Paper›PMID 40178080›Full record

ArticleeLife2025

Simultaneous cyclin D1 overexpression and p27

Zhifei Wu, Baoshan Liao, Julia Ying, Jan Keung, Zongli Zheng, Virpi Ahola, Wenjun Xiong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
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  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhifei Wu *Department of Biomedical Sciences and Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong, China.
Baoshan Liao *Department of Biomedical Sciences and Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0009-0007-6599-624X
Julia YingDepartment of Biomedical Sciences and Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0009-0006-4574-1058
Jan KeungDepartment of Biomedical Sciences and Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong, China.
Zongli ZhengDepartment of Biomedical Sciences and Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0000-0003-4849-4903
Virpi AholaMing Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong, China.
Wenjun XiongDepartment of Biomedical Sciences and Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0000-0001-6836-2807

Funding

Health and Medical Research Fund 05160276Health and Medical Research Fund 06172466Research Grants Council, University Grants Committee 11100723Research Grants Council, University Grants Committee 11102922Research Grants Council, University Grants Committee 11103819
6 · The paper itself

Abstract

Harnessing the regenerative potential of endogenous stem cells to restore lost neurons is a promising strategy for treating neurodegenerative disorders. Müller glia (MG), the primary glial cell type in the retina, exhibit extraordinary regenerative abilities in zebrafish, proliferating and differentiating into neurons post-injury. However, the regenerative potential of mouse MG is limited by their inherent inability to re-enter the cell cycle, constrained by high levels of the cell cycle inhibitor p27

Indexed as

Cell CycleCyclin D1Cyclin-Dependent Kinase Inhibitor p27Ependymoglial CellsRetinaAnimalsCell ProliferationDependovirusGene Knockdown TechniquesMiceNeurogliaCcnd1 protein, mouseCdkn1b protein, mouseCyclin D1Cyclin-Dependent Kinase Inhibitor p27cell cycle regulatorcyclin D1mouseMüller gliap27kip1regenerationregenerative medicineretinastem cells

Identifiers

PMID40178080
PMCPMC11968108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.