ArticleIBRO neuroscience reports2025
Quercetin-loaded nanophytosome ameliorates early life stress-induced hippocampal oxido-inflammatory damages.
Article in IBRO neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Modulation of the AMPK/TFEB Axis by Ezetimibe Attenuates Neuroinflammatory, Oxidative Stress, and Neurotransmitter Dysregulation in Naloxone-precipitated Tramadol Withdrawal in Mice.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026Article
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Abstract
Phytosome-based nanocarriers have emerged as innovative drug delivery systems in recent years, demonstrating significant potential in the treatment of neurodegenerative disorders. This study aimed to evaluate the therapeutic efficacy of quercetin-loaded nanophytosome (QNP) in modulating the oxido-inflammatory response in a rat model of early life stress (ELS) induced by maternal isolation (MI). To establish the ELS model, male rat pups were isolated from their dam for 3 hours daily from postnatal days 1-9. Following the lactation period (postpartum days 1-21), treatments with quercetin (10 and 40 mg/kg) and QNP (10 and 40 mg/kg) were administered continuously for 21 days. Cognitive behaviors, oxidative stress markers, hippocampal dopamine levels, and mRNA expression of TNF-α and IL-6 were assessed after ELS induction. Treatment with QNP (40 mg/kg) significantly improved cognitive function (
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