ArticleJournal of clinical tuberculosis and other mycobacterial diseases2025
Diagnostic accuracy study of STANDARD TB-Feron FIA and STANDARD TB-Feron ELISA tests for tuberculosis infection diagnosis in Eastern European setting.
Article in Journal of clinical tuberculosis and other mycobacterial diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic Performance of New Commercial Interferon-Gamma Release Assays for Mycobacterium tuberculosis Infection: An Updated Systematic Review and Meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Pooled it
- Diagnostic Accuracy of the STANDARD F TB-Feron FIA Assay for Tuberculosis Infection in Vietnam: A Cross-Sectional Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Evaluation of diagnostic agreement between STANDARD E TB-Feron ELISA and TB-Feron FIA for tuberculosis infection in prison settings in Paraguay.Frontiers in public health · 2026Article
- Performance evaluation of the AFIAS IGRA-TB (IFN-gamma) test versus QuantiFERON®-TB gold plus (QFT®-Plus) ELISA in the Barrio Obrero hospital network, Asunción-Paraguay, 2025.Frontiers in public health · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Tuberculosis infection (TBI) is diagnosed based on a positive immune response to Methods: At Chiril Draganiuc Phthisiopneumology Institute in the Republic of Moldova, we prospectively enrolled three cohorts of adults: healthy individuals with no known close contact with TB, patients with active tuberculosis (TB), and individuals with a history of TB. The active TB and past TB cohorts were used to assess the tests' sensitivity, while the healthy group was used to evaluate specificity. Both qualitative and quantitative results from the TB-Feron ELISA and TB-Feron FIA were compared with those of QuantiFERON. Results: The TB-Feron-FIA demonstrated a sensitivity of 80.58 % (95 %CI: 71.90-87.06) in the active TB cohort and 82.93 % (95 %CI: 68.74-91.47) in the past TB cohort, with a specificity of 85.19 % (95 % CI: 73.40-92.30). The TB-Feron-ELISA showed a sensitivity of 80.58 % (95 %CI: 71.90-87.06) in the active TB cohort and 78.57 % (95 %CI: 64.06-88.29) in the past TB cohort, with a specificity of 85.19 % (95 %CI: 73.40-92.30). The agreement coefficient (κ) with QuantiFERON was 0.766 (95 %CI: 0.689-0.843) for TB-Feron-FIA and 0.809 (95 %CI: 0.739-0.880) for TB-Feron-ELISA. Conclusions: Both the TB-Feron-ELISA and TB-Feron-FIA demonstrated good diagnostic accuracy for identifying individuals with TBI, comparable to the performance of QuantiFERON.
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