Evidence map›Paper›PMID 40177553›Full record

ArticleActa pharmaceutica Sinica. B2025

Synthesis, preclinical evaluation and pilot clinical study of a P2Y

Bolin Yao, Yanyan Kong, Jianing Li, Fulin Xu, Yan Deng, Yuncan Chen, Yixiu Chen, Jian Chen, Minhua Xu, Xiao Zhu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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  5. [Acta pharmaceutica Sinica. B · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Bolin YaoSchool of Pharmacy, MOE Key Laboratory of Smart Drug Delivery, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Zhongshan Hospital, Fudan University, Shanghai 201203, China.
Yanyan KongPET Center, Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
Jianing LiSchool of Pharmacy, MOE Key Laboratory of Smart Drug Delivery, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Zhongshan Hospital, Fudan University, Shanghai 201203, China.
Fulin XuDepartment of Neurosurgery, Minhang Hospital, Fudan University, Shanghai 201199, China.
Yan DengSchool of Pharmacy, MOE Key Laboratory of Smart Drug Delivery, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Zhongshan Hospital, Fudan University, Shanghai 201203, China.
Yuncan ChenDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
Yixiu ChenDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
Jian ChenSchool of Pharmacy, MOE Key Laboratory of Smart Drug Delivery, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Zhongshan Hospital, Fudan University, Shanghai 201203, China.
Minhua XuDepartment of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai 201203, China.
Xiao ZhuDepartment of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai 201203, China.
Liang ChenDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
Fang XiePET Center, Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
Xin ZhangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
Cong WangSchool of Pharmacy, MOE Key Laboratory of Smart Drug Delivery, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Zhongshan Hospital, Fudan University, Shanghai 201203, China.
Cong LiSchool of Pharmacy, MOE Key Laboratory of Smart Drug Delivery, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Zhongshan Hospital, Fudan University, Shanghai 201203, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the brain's resident immune cells, microglia perform crucial functions such as phagocytosis, neuronal network maintenance, and injury restoration by adopting various phenotypes. Dynamic imaging of these phenotypes is essential for accessing brain diseases and therapeutic responses. Although numerous probes are available for imaging pro-inflammatory microglia, no PET tracers have been developed specifically to visualize anti-inflammatory microglia. In this study, we present an

Indexed as

AgingBrain diseasesEpilepsyGliomaMicrogliaNeuroinflammationP2Y12 receptorPositron emission tomography (PET)

Identifiers

PMID40177553
PMCPMC11959935

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.