Evidence map›Paper›PMID 40177540›Full record

ArticleActa pharmaceutica Sinica. B2025

Induction of Cyp2e1 contributes to asparaginase-induced hepatocyte sensitization to lipotoxicity.

Yin Zhu, Yuyin Wang, Keito Hoshitsuki, Da Yang, Lauren Kokai, Xiaochao Ma, Wen Xie, Christian A Fernandez

Abstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yin ZhuCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Yuyin WangCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Keito HoshitsukiCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Da YangCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Lauren KokaiDepartment of Plastic Surgery, University of Pittsburgh and the McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15261, USA.
Xiaochao MaCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Wen XieCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Christian A FernandezCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Funding

Improving the disposition of antileukemic asparaginase after drug-induced immunotoxicityR01CA216815 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FERNANDEZ, CHRISTIAN ANTONIO · 2017 to 2021
$1.6M
Human Liver Tissue & Hepatocytes Research Resource (HLTHRR)R24DK139775 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAVID A GELLER, Satdarshan Singh Monga · 2024 to 2026
$1.4M
Mechanistic Study of PEG-asparaginase-Induced Liver InjuryR01DK140079 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Christian Antonio Fernandez · 2024 to 2026
$1.2M
NCI NIH HHS R01 CA216815NIDDK NIH HHS R01 DK140079NIDDK NIH HHS R24 DK139775
6 · The paper itself

Abstract

One of the leading therapies for acute lymphoblastic leukemia (ALL) is the chemotherapeutic agent PEGylated

Indexed as

AsparaginaseATGLCyp2e1LipolysisLipotoxicityLiver injuryOxidative stress

Identifiers

PMID40177540
PMCPMC11959929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.