ArticleOpen life sciences2025
Langerhans cell histiocytosis in an adult patient with upper jaw and pulmonary involvement: A case report.
Article in Open life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Langerhans cell histiocytosis (LCH) is characterized by proliferative histiocyte-like cells. LCH lesions exhibit diverse and nonspecific clinical features, often leading to misdiagnosis and delayed treatment. Primary LCH lesions in the oral cavity remain rare. We report a case of a 27-year-old man with rare adult-onset LCH presenting with progressive mobility of the posterior teeth. The patient experienced increasing tooth mobility and subsequent loss in the upper and lower jaw despite undergoing periodontal treatment. A biopsy of oral mucosal tissue confirmed the Langerhans cell origin. High-resolution computed tomography imaging revealed pulmonary involvement. After undergoing systemic chemotherapy with prednisolone, vinblastine, and etoposide, the patient exhibited favourable follow-up outcomes. This case underscores the value of early diagnosis to prevent disease progression and highlights the need for dentists to be aware of LCH.
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